Person
Evans, Todd
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Biography and Research Interest
Regulation of organogenesis by embryonic signaling pathways and GATA transcription factors
The laboratory focuses primarily on the function and regulation (via BMP, WNT, etc. signaling) of a group of vertebrate transcriptional regulatory proteins called GATA factors. These proteins function to regulate a variety of cell specification, differentiation, and morphogenetic programs during embryogenesis and throughout life. There are two major programs in the lab, studying erythropoiesis (red blood cell development) and cardiogenesis (heart development). WE are also interested in how organs interact during development (e.g. liver and heart). In addition to using zebrafish, we also use murine and human ESC models to understand the role of GATA factors in various disease states.
One of the current goals of the laboratory is to develop new transgenic tools, for analyzing cis-regulatory sequences, and for targeting gene expression to specific lineages. We also have new projects in chemical biology.
The laboratory focuses primarily on the function and regulation (via BMP, WNT, etc. signaling) of a group of vertebrate transcriptional regulatory proteins called GATA factors. These proteins function to regulate a variety of cell specification, differentiation, and morphogenetic programs during embryogenesis and throughout life. There are two major programs in the lab, studying erythropoiesis (red blood cell development) and cardiogenesis (heart development). WE are also interested in how organs interact during development (e.g. liver and heart). In addition to using zebrafish, we also use murine and human ESC models to understand the role of GATA factors in various disease states.
One of the current goals of the laboratory is to develop new transgenic tools, for analyzing cis-regulatory sequences, and for targeting gene expression to specific lineages. We also have new projects in chemical biology.
Non-Zebrafish Publications
Kostetskii, I., Jiang, Y., Kostetskaia, E., Yuan, S., Evans, T., and Zile, M. Retinoid Signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation. Dev. Biol. 206: 206-218, 1999.Mano, T., Luo, Z., Malendowicz, S.L., Evans, T., and Walsh, K. Reversal of GATA-6 Downregulation Promotes Smooth Muscle Differentiation and Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery. Circ. Res. 84: 647-654, 1999.
Rekhtman, N. Radparvar, F., Evans, T. and Skoultchi, A.I. Direct Interaction of Hematopoietic Transcription Factors PU.1 and GATA-1: Functional Antagonism in Erythroid Cells. Genes and Dev. 13: 1398-1411, 1999.
Jiang, Y., Drydale, T., and Evans, T. A Role for GATA-4/5/6 in the Regulation of Nkx2.5 Expression with Implications for Patterning of the Precardiac Field. Dev. Biol. 216: 57-71, 1999.
MacNeil, C., French, R., Evans, T., Wessels, A., and Burch, J.B.E. Modular Regulation of cGATA-5 Gene Expression in the Developing Heart and Gut. Dev. Biol. 217: 62-76, 2000.
Ghatpande, S., Ghatpande, A., Zile, M., and Evans, T. Anterior Endoderm is Sufficient to Rescue Foregut Apoptosis and Heart Tube Morphogenesis in an Embryo Lacking Retinoic Acid. Dev. Biol. 219: 59-70, 2000.