| Name: |
JNK cascade |
| Synonyms: |
c-Jun N-terminal kinase cascade,
JNK1 cascade,
JNK2 cascade,
JNK3 cascade,
MAPK10 cascade,
MAPK8 cascade,
MAPK9 cascade,
SAPK cascade,
stress-activated protein kinase cascade
|
| Definition: |
A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. |
| Ontology: |
GO: Biological Process [GO:0007254]
QuickGO
AmiGO
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