Search Ontology:
GO: Biological Process

JNK cascade

Term ID
GO:0007254
Synonyms
  • c-Jun N-terminal kinase cascade
  • JNK1 cascade
  • JNK2 cascade
  • JNK3 cascade
  • MAPK10 cascade
  • MAPK8 cascade
  • MAPK9 cascade
  • SAPK cascade
  • stress-activated protein kinase cascade
Definition
A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. (3)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
has parts
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes