Search Ontology:
GO: Biological Process

siRNA-mediated post-transcriptional gene silencing

Term ID
GO:0140766
Synonyms
  • gene silencing by siRNA
  • post-transcriptional gene silencing by siRNA
  • posttranscriptional gene silencing by siRNA
  • siRNA-mediated gene silencing
  • siRNA-mediated PTGS
Definition
A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants. 26372022
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
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has subtype
Phenotype
Phenotype caused by Genes