siRNA-mediated gene silencing by mRNA destabilization

Term ID

GO:0090625

Synonyms

• gene silencing by mRNA cleavage
• mRNA cleavage involved in gene silencing by siRNA
• mRNA destabilization-mediated gene silencing by siRNA

Definition

An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA. 15260970

References

Ontology

GO: Biological Process    QuickGO    AmiGO