ERBB2-EGFR signaling pathway

Term ID

GO:0038134

Synonyms

• EGFR-HER2 signaling pathway
• ERBB2-EGFR signalling pathway

Definition

The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. 16460914

References

Ontology

GO: Biological Process    QuickGO    AmiGO