Search Ontology:
GO: Biological Process

negative regulation of insulin receptor signaling pathway by insulin receptor internalization

Term ID
GO:0038014
Synonyms
  • agonist-stimulated insulin receptor internalization
  • negative regulation of insulin receptor signalling pathway by insulin receptor internalization
Definition
Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation. (4)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
negatively regulates
Phenotype
Phenotype caused by Genes