miRNA-mediated gene silencing by mRNA destabilization

Term ID

GO:0035279

Synonyms

• gene silencing by miRNA, mRNA cleavage
• gene silencing by mRNA cleavage
• miRNA-mediated gene silencing by mRNA deadenylation
• miRNA-mediated gene silencing, mRNA cleavage
• mRNA cleavage involved in gene silencing by microRNA
• mRNA cleavage involved in gene silencing by miRNA
• mRNA destabilization-mediated gene silencing by miRNA

Definition

An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. (4)

References

Ontology

GO: Biological Process    QuickGO    AmiGO