Search Ontology:
GO: Biological Process

miRNA-mediated post-transcriptional gene silencing

Term ID
GO:0035195
Synonyms
  • gene silencing by microRNA
  • gene silencing by miRNA
  • microRNA-mediated gene silencing
  • miRNA-mediated gene silencing
Definition
A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. (6)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
has parts
is a type of
has subtype
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes