miRNA-mediated post-transcriptional gene silencing

Term ID

GO:0035195

Synonyms

• gene silencing by microRNA
• gene silencing by miRNA
• microRNA-mediated gene silencing
• miRNA-mediated gene silencing

Definition

A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. (6)

References

• Reactome:R-HSA-9759811

Ontology

GO: Biological Process    QuickGO    AmiGO