cortistatins

Term ID

CHEBI:67169

Synonyms

Definition

Any member of a class of steroidal alkaloids obtained from the marine sponge Corticium simplex, with a basic skeleton that is (5R,8beta)-5,8-epoxy-9,19-cyclo-9,10-secoandrostane, bearing a dimethylamino substituent at position 3 and an isoquinolin-7-yl or isoquinolin-7-yl-derived substituent at position 17. They selectively inhibit proliferation of human umbilical vein endothelial cells (HUVECs).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: polycyclic ether steroid alkaloid tertiary amino compound

polycyclic ether steroid alkaloid tertiary amino compound Show first 5 Terms
has subtype: cortistatin A cortistatin B cortistatin C cortistatin D cortistatin E

cortistatin A cortistatin B cortistatin C cortistatin D cortistatin E Show first 5 Terms
has_role: angiogenesis modulating agent

angiogenesis modulating agent Show first 5 Terms

Phenotype

Phenotype resulting from cortistatins

Phenotype where environments contain cortistatins

Phenotype modified by environments containing cortistatins

Human Disease Model