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ChEBI

phorbol 13-acetate 12-myristate

Term ID
CHEBI:37537
Synonyms
  • (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
  • 12-O-tetradecanoylphorbol 13-acetate
  • 12-tetradecanoylphorbol 13-acetate
  • phorbol 12-myristate 13-acetate
  • phorbol 12-tetradecanoate 13-acetate
  • phorbol-12-myristate-13-acetate
  • PMA
  • tetradecanoylphorbol acetate
  • TPA
Definition
A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from phorbol 13-acetate 12-myristate
Phenotype where environments contain phorbol 13-acetate 12-myristate
Phenotype modified by environments containing phorbol 13-acetate 12-myristate
Human Disease Model
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