phorbol ester

Term ID

CHEBI:37532

Synonyms

phorbol ester

Definition

Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: carboxylic ester diterpenoid tetracyclic diterpenoid

carboxylic ester diterpenoid tetracyclic diterpenoid Show first 5 Terms
has subtype: 4-deoxyphorbol 12-acetate 13-(2Z,4E,6E)-deca-2,4,6-trienoate 4alpha-phorbol 12,13-didecanoate 12-deoxyphorbaldehyde-13-hexadecanoate 12-deoxyphorbol 20-acetate 13-(2-methylbutanoate) 12-deoxyphorbol-13,20-diacetate ... Show All 29 Terms

4-deoxyphorbol 12-acetate 13-(2Z,4E,6E)-deca-2,4,6-trienoate 4alpha-phorbol 12,13-didecanoate 12-deoxyphorbaldehyde-13-hexadecanoate 12-deoxyphorbol 20-acetate 13-(2-methylbutanoate) 12-deoxyphorbol-13,20-diacetate 12-deoxyphorbol-13-(3E,5E-decadienoate) 12-deoxyphorbol-13-hexadecanoate 12-O-Decanoylphorbol-13-acetate 12b-O-[Deca-2Z,4E-dienoyl]-13a-isobutyl-5-ene-7-oxo-4b-phorbol 16-hydroxyphorbol 13-decanoate 12-palmitate [(1S,6R,10S,13S,14R,15R)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-14-[(E)-2-methylbut-2-enoyl]oxy-5-oxo-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] 2-methylbutanoate [1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-13-(2-methylpropanoyloxy)-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] (E)-2-methylbut-2-enoate [13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] (E)-2-methylbut-2-enoate Candletoxin A LSM-4341 pedilstatin phorbol 12,13-dibutanoate phorbol 13-acetate phorbol 13-acetate 12-myristate phorbol 13-butanoate phorbol 13-decanoate 12-tiglate prostratin rel-12-O-(4Z)-Deca-4-enoylphorbol-13-acetate rel-12-O-(4Z,7Z)-Deca-4,7-dienoylphorbol-13-acetate rel-12-O-Octanoylphorbol-13-acetate rel-16-Angeloyloxy-13alpha-isobutanoyloxy-4beta,9alpha,7beta-trihydroxytiglia-1,5-dien-3-one rel-16-Angeloyloxy-13alpha-isobutanoyloxy-4beta,9alpha,20-trihydroxytiglia-1,5-diene-3,7-dione sapintoxin D tigilanol tiglate Show first 5 Terms
has_functional_parent: phorbol

phorbol Show first 5 Terms

Phenotype

Phenotype resulting from phorbol ester

Phenotype where environments contain phorbol ester

Phenotype modified by environments containing phorbol ester

Human Disease Model