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Phenotype Figure Summary
Marker:
vcp
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Voisard
et al.
, 2022
Fig. 1
vcp
ulm105/ulm105
whole organism Ab2-vcp labeling absent, abnormal
whole organism dead, abnormal
whole organism morphology, abnormal
whole organism viability, abnormal
Fig. 2
vcp
ulm105/ulm105
, 
WT + MO3-vcp
muscle cell inclusion body increased amount, abnormal
muscle cell mitochondrion morphology, abnormal
myotome muscle cell broken, abnormal
myotome muscle cell disorganized, abnormal
whole organism swimming decreased process quality, abnormal
Fig. 3
vcp
ulm105/ulm105
cardiac muscle cell mitochondrion morphology, abnormal
heart cardiac muscle cell disorganized, abnormal
heart heart contraction decreased process quality, abnormal
Fig. 4
vcp
ulm105/ulm105
whole organism ab1-rps6 labeling increased amount, abnormal
whole organism Ab12-hspa5 labeling increased amount, abnormal
whole organism Ab4-ub labeling increased amount, abnormal
whole organism response to endoplasmic reticulum stress increased process quality, abnormal
Kustermann
et al.
, 2018
Fig. 1
WT + MO4-vcp
, 
WT + MO3-vcp
blood circulation decreased magnitude, abnormal
heart contraction decreased frequency, abnormal
heart contraction decreased magnitude, abnormal
heart edematous, abnormal
involuntary skeletal muscle contraction decreased occurrence, abnormal
myotome skeletal muscle malformed, abnormal
thigmotaxis decreased occurrence, abnormal
whole organism
vcp
expression absent, abnormal
whole organism
vcp
expression decreased amount, abnormal
Fig. 2
WT + MO4-vcp
myotome skeletal muscle cell has extra parts of type skeletal muscle cell vesicle, abnormal
myotome skeletal muscle malformed, abnormal
skeletal muscle cell Z disc malformed, abnormal
skeletal muscle mitochondrion malformed, abnormal
skeletal muscle skeletal muscle myofibril disorganized, abnormal
skeletal muscle skeletal myofibril assembly decreased process quality, abnormal
Fig. 3
WT + MO4-vcp
autophagy decreased occurrence, abnormal
proteasome-mediated ubiquitin-dependent protein catabolic process decreased occurrence, abnormal
whole organism ab1-map1lc3 labeling increased amount, abnormal
whole organism Ab4-ub labeling increased amount, abnormal
whole organism Ab7-sqstm1 labeling increased amount, abnormal
Bührdel
et al.
, 2015
Fig. 2
WT + MO3-vcp
locomotion disrupted, abnormal
thigmotaxis disrupted, abnormal
whole organism decreased mobility, abnormal
Imamura
et al.
, 2012
Fig. 1
WT + MO2-vcp
embryo development delayed, abnormal
eye size, abnormal
head size, abnormal
trunk curved ventral, abnormal
Fig. 2
rw0Tg + MO2-vcp
, 
WT + MO2-vcp
brain degeneration, abnormal
cranial nerve II decreased width, abnormal
diencephalon cell decreased amount, abnormal
eye degeneration, abnormal
motor neuron axon branched, abnormal
motor neuron axon truncated, abnormal
retinal ganglion cell layer decayed, abnormal
retinal inner plexiform layer decayed, abnormal
Fig. 3
WT + MO2-vcp
diencephalon nucleus aggregated, abnormal
eye nucleus aggregated, abnormal
retinal ganglion cell layer neuron degenerate, abnormal
retinal inner plexiform layer neuron degenerate, abnormal
Fig. 4
WT + MO2-vcp
eye size, abnormal
head size, abnormal
trunk curved ventral, abnormal
Fig. S2
WT + MO2-vcp
trunk curved ventral, abnormal
Fig. S3
WT + MO2-vcp
brain apoptotic, abnormal
diencephalon apoptotic, abnormal
eye apoptotic, abnormal
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