Publication	Data		Fish	Anatomy
Shao et al., 2022	Fig. 6		insrbihb358/ihb358	whole organism glucose increased amount, abnormal
Qi et al., 2021	Figure 5		y1Tg + MO3-insrb	hyaloid vessel increased branchiness, abnormal hyaloid vessel sprouting angiogenesis increased process quality, abnormal whole organism glucose increased amount, abnormal
Gong et al., 2018	Fig. 1		insrbihb358/ihb358	blood glucose increased amount, abnormal whole organism increased weight, abnormal
	Fig. 2		insrbihb358/ihb358	liver gck expression decreased amount, abnormal liver gck expression increased amount, abnormal liver hk1 expression decreased amount, abnormal liver ldha expression decreased amount, abnormal liver ldha expression increased amount, abnormal liver pfklb expression decreased amount, abnormal liver pklr expression decreased amount, abnormal
	Fig. 3		insrbihb358/ihb358	liver pyruvate kinase activity decreased occurrence, abnormal
	Fig. 4		insrbihb358/ihb358	muscle gck expression decreased amount, abnormal muscle hk1 expression decreased amount, abnormal muscle ldha expression decreased amount, abnormal muscle ldha expression increased amount, abnormal muscle pfkma expression decreased amount, abnormal muscle pfkma expression increased amount, abnormal muscle pkma expression decreased amount, abnormal muscle pyruvate kinase activity decreased occurrence, abnormal
	Fig. 5		insrbihb358/ihb358	liver g6pc1a.1 expression decreased amount, abnormal liver g6pc1a.1 expression increased amount, abnormal liver pck1 expression decreased amount, abnormal liver pck1 expression increased amount, abnormal
	Fig. 6		insrbihb358/ihb358	liver glucose-6-phosphatase activity decreased occurrence, abnormal liver phosphoenolpyruvate carboxykinase activity decreased occurrence, abnormal liver phosphoenolpyruvate carboxykinase activity increased occurrence, abnormal
	Fig. 7		insrbihb358/ihb358	blood plasma insulin increased amount, abnormal liver ab5-akt labeling decreased amount, abnormal
	Fig. 8		insrbihb358/ihb358	whole organism foxo1a expression decreased amount, abnormal whole organism foxo1a expression increased amount, abnormal
Yang et al., 2017	Fig. 3		insrbihb358/ihb358	whole organism glucose decreased amount, abnormal
	Fig. 6		insrbihb358/ihb358	digestive system g6pc1a.1 expression increased amount, abnormal digestive system gck expression decreased amount, abnormal whole organism g6pc1a.1 expression increased amount, abnormal whole organism gck expression decreased amount, abnormal whole organism hkdc1 expression decreased amount, abnormal whole organism idh3b expression decreased amount, abnormal whole organism pklr expression decreased amount, abnormal
Yang et al., 2017	Fig. 1		insrbihb358/ihb358	blood glucose increased amount, abnormal liver aldoaa expression decreased amount, abnormal liver g6pc1a.1 expression decreased amount, abnormal liver gck expression decreased amount, abnormal liver gpia expression decreased amount, abnormal liver hkdc1 expression decreased amount, abnormal liver pklr expression decreased amount, abnormal liver Ab1-gck labeling decreased amount, abnormal liver ab5-akt labeling decreased amount, abnormal
	Fig. 2		insrbihb358/ihb358	feeding behavior increased rate, abnormal liver Ab3-prkaa labeling decreased amount, abnormal
	Fig. 3		insrbihb358/ihb358	liver lipid increased amount, abnormal visceral fat increased amount, abnormal
	Fig. 4		insrbihb358/ihb358	blood plasma cholesterol increased amount, abnormal blood plasma fatty acid increased amount, abnormal blood plasma phospholipid increased amount, abnormal blood plasma triglyceride increased amount, abnormal liver triglyceride increased amount, abnormal
	Fig. 5		insrbihb358/ihb358	hypophysis gh1 expression increased amount, abnormal liver Ab1-igf1 labeling decreased amount, abnormal liver Ab2-ppara labeling decreased amount, abnormal muscle ab1-rps6 labeling decreased amount, abnormal muscle ab3-stat5 labeling decreased amount, abnormal
	Fig. 6		insrbihb358/ihb358	adipose tissue fas expression increased amount, abnormal adipose tissue pparg expression increased amount, abnormal liver acaca expression increased amount, abnormal liver acsl1b expression increased amount, abnormal liver cpt1b expression increased amount, abnormal liver cpt2 expression increased amount, abnormal liver elovl5 expression increased amount, abnormal liver fabp1a expression increased amount, abnormal liver fads2 expression decreased amount, abnormal liver fas expression decreased amount, abnormal liver foxo1a expression decreased amount, abnormal liver irs2a expression decreased amount, abnormal liver lipca expression increased amount, abnormal liver mknk2b expression decreased amount, abnormal liver pde3b expression decreased amount, abnormal liver pik3ca expression decreased amount, abnormal liver pik3cd expression decreased amount, abnormal liver ppp1caa expression decreased amount, abnormal liver ppp1r3da expression decreased amount, abnormal liver prkag2a expression decreased amount, abnormal liver pygmb expression decreased amount, abnormal liver shc2 expression decreased amount, abnormal liver socs1a expression decreased amount, abnormal liver socs2 expression decreased amount, abnormal muscle bcat1 expression decreased amount, abnormal muscle eif4ebp1 expression increased amount, abnormal muscle ulk2 expression increased amount, abnormal
	Fig. 7		insrbihb358/ihb358	lipid biosynthetic process increased occurrence, abnormal
Toyoshima et al., 2008	Fig. 6		WT + MO1-insrb	eye decreased size, abnormal forebrain decreased size, abnormal mandibular arch skeleton malformed, abnormal midbrain decreased size, abnormal pericardium edematous, abnormal