FIGURE

Figure 5

ID

ZDB-FIG-210930-12

Publication

Qi et al., 2021 - Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

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Figure 5

insra/insrb expression silencing induced vascular alterations and caused higher glucose level at 5 dpf. A) Representative confocal images of hyaloid vasculature. White scale bar: 20 µm. B,C) Quantification of hyaloid vasculature showed significant increasing numbers of branches and sprouts in larvae upon insra/insrb silencing at 5 dpf. n = 12–14. D) Whole‐body glucose measurement showed higher glucose level in akr1a1a1^+/+ larvae upon insra/insrb silencing at 5 dpf. n = 3–6 clutches with 20 larvae. For statistical analysis one‐way ANOVA followed by Tukey's multiple comparisons test was applied. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg + MO3-insra y1Tg + MO3-insrb
Knockdown Reagents:	MO3-insra MO3-insrb
Observed In:	hyaloid vessel hyaloid vessel sprouting angiogenesis whole organism glucose
Stage:	Day 5

Phenotype Detail

Acknowledgments

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