Genomic Feature
umo17
- ID
- ZDB-ALT-200630-1
- Name
- umo17
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Wei Ge Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 22: 20761539 - 20761542 (GRCz11) (1) Details
- Nucleotide change
- ACAG/CGTCGTATTGTATTGTGCTCGTCGTATTGTGCGATTGGGTCGTATTGTGTGGGTCGTATTGTGCTA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 66 bp inserted / 4 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AAAGGACAGAACACTGGATCACTACAAACATCCAGGACGGTGTTTTTGAATCTAAACTCTGCAGAAAATTAACATTTCAGAATCAAGGTTGTTGATTTAACATCTTCCCCAAACTTGACAAAAACCTTTTCCCAAACTCACGTAGCAACTTAATCTTCATCCATTTATACAAATAAATTTAAGGAATCATCAGACTATTCACATCAAAAGTTACTATTTATTCCTTTAGCAGGTTAACCTATGACAGTGATTCTCAACTCCAGCCGGTGGGACACTCCTCCCAGAATGTGGAGACGTCCTACACGCTAAGAAATTGTTGAGTTAAACCAGTAAGAAAACATTTTTGGGGACTGGAGGTGAGAAACTAATCTCTGAAATGTAAAAAAAATACAAAACAATCCCATGAAATCATCAATACATCCCACGACACAGATGTGGGACGAATGACTGACCTGATAGCGGGTTGACCTTCGGGTTGTTGTCCTGCTCTTCGTGCCTCA
ACAG/CGTCGTATTGTATTGTGCTCGTCGTATTGTGCGATTGGGTCGTATTGTGTGGGTCGTATTGTGCTA AGCACAATACGACCCAATCGCCACGGTCATCATCAGCATCAGCCCAAATCTTGCCTGGAAAAGCATCTTCTCACATTCAGTCAGAAATCCAGCACTTTTTGGGTTGGGTCTGCGGCGGGGGACGTGTTTTATACACGCGTCCTCTTGCTCTCCTGAGTGGAGTCAGACTGCCAAAAAGCGTGTCCTTGGAGTAACAGTGGGTATTTGAGGCATGCGAGTGGACGTGTGAATTTTGAGGGATAGTGAATGGACATCACATGCCTTGAGTTTTGATAAGGTGAGGAGGAACTCATACTGACAATGGAATATTGTATAGACCTCAGACACATCTGTAGTAGCGGATAACGGTTTAAGACTCCTTGTTGGCAAATTGCAACAAAGTTCTATTCTTAGTTTAGCCCTTCATTCCCATGGGATGGCAGTTAGGCTTCTTTTTCTGTCCGGGCAGATTTTTGTTAACCCACCAAACTGTAAGATGTTCACATTAAGAAACTTTTTAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| amhumo17/umo17 | Homozygous | ♀+/- ♂+/- | 3 figures  from Zhang et al., 2020 | 4 figures from Zhang et al., 2020 | |
| amhumo17/+ | Heterozygous | ♀+/- ♂+/- | 4 figures from Zhang et al., 2020 | ||
| bmpr2aumo25/+; amhumo17/+ (AB) | Complex | Fig. 4 from Zhang et al., 2020 | Fig. 4 from Zhang et al., 2020 | ||
| bmpr2aumo25/+; amhumo17/umo17 (AB) | Complex | Fig. 4 from Zhang et al., 2020 | Fig. 4 from Zhang et al., 2020 | ||
| bmpr2aumo25/umo25; amhumo17/+ (AB) | Complex | Fig. 4 from Zhang et al., 2020 | Fig. 4 from Zhang et al., 2020 | ||
| bmpr2aumo25/umo25; amhumo17/umo17 (AB) | Complex | Fig. 4 from Zhang et al., 2020 | |||
| bmpr2aumo25/umo25; amhumo17/umo17 (AB) | Complex | Fig. 4 from Zhang et al., 2020 | Fig. 4 from Zhang et al., 2020 | ||
| fshbumo1/+; amhumo17/+ | Complex | Fig. 7 from Zhang et al., 2020 | |||
| fshbumo1/+; amhumo17/+ (AB) | Complex | Fig. 1 from Zhang et al., 2020 | |||
| fshbumo1/+; amhumo17/umo17 | Complex | Fig. 7 from Zhang et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Zhang, Z., Wu, K., Ren, Z., Ge, W. (2020) Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signalling through Bmpr2a receptor. Development (Cambridge, England). 147(22):
- Zhang, Z., Zhu, B., Chen, W., Ge, W. (2020) Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish. Molecular and Cellular Endocrinology. 517:110963
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