Genomic Feature
mde198
- ID
- ZDB-ALT-170607-9
- Name
- mde198
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Schmid Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 6: 45946203 - 45946221 (GRCz11) (1) Details
- Nucleotide change
- ACCCCCCTCATGCACTGAG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 19 bp deleted in Exon 2 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AATATGTGAGCATATTTACTGTACAAAACCTGTCAGTGAACTGTGAGGGCAAAAAAAAAAAAAAAAAAATTTAATTGTAATTTTTAATTAATTGAGATCTTGATTTTAGGCCAAATCGCCCAGCCCTATTTCCTACCACTGCTCTCTTGCTTGTCTGACTTGCTGTAATGTTCAAATTTAAATTAATCAGAGGTTTTATTCTATTTTTTTGCCACCTATGCCAAGCTGTTTTAACACAACCTACATTTTAAAAAGCACAACAGAAATAAAGATGAACTGAAAACTGTGACCATGCATTAGAGGAGAAAAAGGTAGATTATAAATGATATTTTATTTTTTAAAGTGTGCAATTGTGCATGTTTTCAGGATGCTTTCTAAAAACATTTTTTAAATTGGGCTTAGTATATTAATTGTACCACATACCTTTTGGGTAATTAACCACATAGACTAGGTTTCCCCAGCCGTTCTCAGGTGCATGCAGAATGCCGTCCACCAGACGA
ACCCCCCTCATGCACTGAG/- ACACTGGGCTCCGGAAGCGCAGACCACAAGCCCCTGGAAACTGAGCGGACACTGTGGAAAGCAAAACCGTGCCATCATCCTCTGACGGGATCTCCATCGGCTCCTCATTCTCCTCCTCCGCAACTCGAATGTACATCTCGGCCATCTTTCCTCAGTCGAGCTGACGGTGAATGAATAGTAAAATTATTGTTTCCATTAGCCAAAAAAGACAAAAACAAAAAAGACAGTAATATCTCATAAAAAATGACCATAACAAAATATGCAAAAAAAACTAAAAGCAAAATGTTTAAATTCACAGCACTCATTTAAAAAAAAAACTTAGATTGGTCGTGAGATCCGAATTAGTAAACAGAAAATAAATGCTTTTGAGAAATCCTTCTGTTTGCAACAGTTTCAACTTTCTTTTTATTCGTACAGAAAACTACAATACACATAAAAACTAATAATGATGATGATGCTCTACAGAAAGTTACCAACATTTCTGCTATTAAGGTACTTTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tardbpbmde198/mde198 (AB) | Homozygous | ♀-/- | text only from Schmid et al., 2013 | ||
| tardbpbmde198/mde198 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 1  from Schmid et al., 2013 | ||
| tardbpamde114/mde114; tardbpbmde198/mde198 (AB) | Complex | text only from Schmid et al., 2013 | |||
| tardbpamde114/mde114; tardbpbmde198/mde198; s896Tg (AB) | Complex | text only from Schmid et al., 2013 | |||
| tardbpamde159/mde159; tardbpbmde198/mde198 (AB) | Complex | text only from Schmid et al., 2013 | |||
| tardbpamde159/mde159; tardbpbmde198/mde198; s896Tg (AB) | Complex | text only from Schmid et al., 2013 | |||
| tardbpamde222/mde222; tardbpbmde198/mde198 | Complex | ||||
| tardbpamde222/mde222; tardbpbmde198/mde198 (AB) | Complex | text only from Schmid et al., 2013 | |||
| tardbpamde222/mde222; tardbpbmde198/mde198; s896Tg (AB) | Complex | text only from Schmid et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Ohki, Y., Wenninger-Weinzierl, A., Hruscha, A., Asakawa, K., Kawakami, K., Haass, C., Edbauer, D., Schmid, B. (2017) Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. Molecular neurodegeneration. 12:6
- Schmid, B., Hruscha, A., Hogl, S., Banzhaf-Strathmann, J., Strecker, K., van der Zee, J., Teucke, M., Eimer, S., Hegermann, J., Kittelmann, M., Kremmer, E., Cruts, M., Solchenberger, B., Hasenkamp, L., van Bebber, F., Van Broeckhoven, C., Edbauer, D., Lichtenthaler, S.F., and Haass, C. (2013) Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 110(13):4986-91
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