Genomic Feature
hu3425
- ID
- ZDB-ALT-080610-11
- Name
- hu3425
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 21391889 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TGCTGTTAACGATGTGGACGAAGGTGAGAGCTCTGATTGTTATTAGTGTTGCAGATCGATTTAATTGCCGTAGCACTGATCAGGAGGCAAAAGTTGATGGGTGTGGGCAGACGATTTCAACCGTTTCTGCTTAAAGTGATCGATATTTGAATTACGCAGCCACATGTGCGCGTGCATTTGGAAATGTCAGATGTAAGAAATGTTAACTTGAAACACGATTCCTCATTAAAAGCACGGGTGGATCAGTTTTATAGGATATTGTATGAAATAAAGCCGATTTTCTCATCTCATCCGCATAACAGGTTTGCAAAATTGTAGACTGATTCTCTGGAGACTTGAATGCACAAGCGCACGCGACACATTCCCTCAAATTAACATTAGCACAGATTTATCTGCATTTCTGTAATGCACAATCAGCATTATGATTGCTCTGTTTGTTTGTTTATTTATTTGTCTTTCTGTTTTTCAATGTATTTTTAGGTGTCCCAGTCCTCTGGCTA
T/A TTTGAGCTGCAGCTGATTGCTGTAGAAAATGTAAACGGTGAGTTGTGGGACGGGGAATGTTGCGACAGCACGCGGAACTCTCAAGACCAGCGCTGCGTGCGGGACGAGTGCGATACTTACTTTAAAGTGTGTCTGAAGGAGTACCAGTCTGAAGTCACCACCACTGGACAGTGCACCTTCGGCTCTGGATCTACCGACGTTCTTGGTGGAAATATAATTTCTTTTAAGACCGCAAAAAACAGCCCCAGCAAAACGAGCGACGTGGGAAAGATCATCATCCCTTTTCACTTCGCCTGGCCGGTGAGTCCTCGTCTTCTCCATGGGCTGTAATAAAAAAACGCGCCGCGGTGAGCTGTCACTGCTCGGAAGTTGAGTGCACTATATTGTTAGGGTGATGACAGGGTCTCTATTTTAATCGTGGGGCGTGTAGGCTGCTGTCTTTTAACGATTTTCTGTTATTTCTGTGACTGCTTCATCTGTAGGGCACTCACTTTGCTCTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| jag2bhu3425/hu3425 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 5  from Abdul-Wajid et al., 2018 | ||
| jag2bhu3425/+ (AB) | Heterozygous | Unknown | Fig. 5 from Abdul-Wajid et al., 2018 | ||
| jag2bhu3425 | Unknown | Unknown | |||
| jag2bhu3425/hu3425; um14Tg | Complex | Fig. 1 from Zhang et al., 2017 | Fig. 1 from Zhang et al., 2017 | ||
| jag1bb1105/b1105; jag2bhu3425/hu3425 | Complex | Fig. 2 from Zhang et al., 2017 | Fig. 2 from Zhang et al., 2017 | ||
| jag1bb1105/b1105; jag2bhu3425/hu3425; gz15Tg | Complex | Fig. 4 from Zhang et al., 2017 | Fig. 4 from Zhang et al., 2017 | ||
| jag1bb1105/b1105; jag2bhu3425/hu3425; gz15Tg; jh1Tg | Complex | Fig. 2 from Zhang et al., 2017 | Fig. 2 from Zhang et al., 2017 | ||
| jag1bb1105/b1105; jag2bhu3425/hu3425; jh1Tg | Complex | 3 figures from Zhang et al., 2017 | 3 figures from Zhang et al., 2017 | ||
| jag1bb1105/b1105; jag2bhu3425/hu3425; um14Tg | Complex | Fig. 1 from Zhang et al., 2017 | Fig. 1 from Zhang et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Wada, Y., Tsukatani, H., Kuroda, C., Miyazaki, Y., Otoshi, M., Kobayashi, I. (2022) Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish. Development (Cambridge, England). 149(7)
- Zhao, C., Matalonga, J., Lancman, J.J., Liu, L., Xiao, C., Kumar, S., Gates, K.P., He, J., Graves, A., Huisken, J., Azuma, M., Lu, Z., Chen, C., Ding, B.S., Dong, P.D.S. (2022) Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201097119e2201097119
- Zhao, C., Lancman, J.J., Yang, Y., Gates, K.P., Cao, D., Barske, L., Matalonga, J., Pan, X., He, J., Graves, A., Huisken, J., Chen, C., Dong, P.D.S. (2021) Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome. Hepatology (Baltimore, Md.). 75(3):567-583
- Abdul-Wajid, S., Demarest, B.L., Yost, H.J. (2018) Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish. Nature communications. 9:4603
- Lai, J.K.H., Collins, M.M., Uribe, V., Jiménez-Amilburu, V., Günther, S., Maischein, H.M., Stainier, D.Y.R. (2018) The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish. Development (Cambridge, England). 145(10)
- Zhang, D., Gates, K.P., Barske, L., Wang, G., Lancman, J.J., Zeng, X.I., Groff, M., Wang, K., Parsons, M.J., Crump, J.G., Dong, P.D.S. (2017) Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nature communications. 8:769
- Han, P., Bloomekatz, J., Ren, J., Zhang, R., Grinstein, J.D., Zhao, L., Burns, C.G., Burns, C.E., Anderson, R.M., Chi, N.C. (2016) Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 534:700-4
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