Gene

jag2b

ID
ZDB-GENE-011128-3
Name
jagged canonical Notch ligand 2b
Symbol
jag2b Nomenclature History
Previous Names
  • jag2
  • jagged2
  • serB
  • serrateB
  • unp1068
  • zgc:152855
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have Notch binding activity and calcium ion binding activity. Involved in animal organ development. Predicted to localize to plasma membrane and protein-containing complex. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
43 figures from 29 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jag2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Muscular dystrophy, limb-girdle, autosomal recessive 27 619566
Associated With jag2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR011651 Notch ligand, N-terminal domain
Family IPR026219 Jagged/Serrate protein
Family IPR050906 Notch signaling pathway
Family IPR051022 Notch Signaling and Cell Fate Determination
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Jagged/Serrate protein Notch ligand, N-terminal domain Notch Signaling and Cell Fate Determination Notch signaling pathway VWFC domain
UniProtKB:Q5TZK7 1216
UniProtKB:Q90Y56 1254
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA jag2b-201 (1) Ensembl 5,438 nt
mRNA jag2b-202 (1) Ensembl 5,324 nt
mRNA jag2b-204 (1) Ensembl 1,407 nt
ncRNA jag2b-003 (1) Ensembl 812 nt
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations