Genomic Feature
gl8
- ID
- ZDB-ALT-070117-12
- Name
- gl8
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Lieschke Laboratory
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 10: 7780718 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AGAGAATAAACACTCATCTAACCTCATTTCCAATGTCTGAAATGTTGATGCCACCATCACCTGGAAGGTCAAACACCAAATCACAGGTGAACTAAACCATGGTCACCGTACCATGATATATGCAATACTTTATATGTGCCTTTACCACCAAAATTAGGTACTCTACAAGCACATATAAAGCAATCAGGAAGTTTAGGCTGAGATTTATGTACAAGCAGAAGGTTTACGTTTAAGCATCCCCAGAAGATTTATGTATAAGCATGCAGCAGTTAAAAGGTACTGTATGATGTCTCACCAGTCTCTTTCCAAGGCTCGAGATCAAAAGCTGGGATATTCCCACAGTTAACAAAATTGGCAGGACTCCGGAAGCGAAAAGGATCTCTGGGAACTTTAAGGATTCCGGTGTTGTCGCAGATTATGCGGGCCAGCGACACAGAGGCCAGAGCTGTTTTCTGTTTGGTGGTGAACACTCCATTGCTCTCAAACCACAACCTAAACAC
A/T AAGCAAGACTTGGCATTAACACCTCTCCAAGACAACTAAATATTTTTCACAAACTTCATTAGGGTGTCCTGACTTCCTACTGCAGTGTCTTGCAGAGTTTAACTCTTAACATGACCCAGCACAGGCGGTGCGGCGGAGCAGTGAGTAGCAAGAAGCCTCGCAGCACTGGTTCGAGCCTCGGCTGGGTCAGTTGGCATTTCTCTGTGGAGTTTGCATGTTTTCCCTTTGTTCAGGTGAGTTTCCACCGCTTTCCCGGTTTCTCCCACAAGTCCAAAGACATGTGCTATAAGCTAAATTGGCCGTAGTGTATGTGTGTGTGAATGAGAATGTATGGGGGTTTCCCAGTGATGGGTTGCAGCTGGAAGGGCATTCGCTGTGTAAAACATATGCTAAATAAGTTGGCACTGTGGCGACCTCTGATTAATAAAGAGAGTAAGCCGAAAAAAAAAAAATTATGAATGACCCAGCACATCTGATGAACTTTCTTAAAGACTTTGATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mpxgl8/gl8 | Homozygous | ♀+/- ♂+/- | 2 figures  from Pase et al., 2012 | Fig. 2 from Pase et al., 2012 | |
| mpxgl8 | Unknown | Unknown | |||
| mpxgl8/gl8; gl23Tg; i113Tg + MO2-irf8 | Complex | Fig. 5 from Ellett et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Black, H.D., Xu, W., Hortle, E., Roberston, S.I., Britton, W.J., Kaur, A., New, E.J., Witting, P.K., Chami, B., Oehlers, S.H. (2019) The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free radical biology & medicine. 135:157-166
- Ellett, F., Pazhakh, V., Pase, L., Benard, E.L., Weerasinghe, H., Azabdaftari, D., Alasmari, S., Andrianopoulos, A., Lieschke, G.J. (2018) Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo. PLoS pathogens. 14:e1007063
- Pase, L., Layton, J.E., Wittmann, C., Ellett, F., Nowell, C.J., Reyes-Aldasoro, C.C., Varma, S., Rogers, K.L., Hall, C.J., Keightley, M.C., Crosier, P.S., Grabher, C., Heath, J.K., Renshaw, S.A., and Lieschke, G.J. (2012) Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish. Current biology : CB. 22(19):1818-1824
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