| ZFIN ID: ZDB-EXP-210429-6 |
Experiment Conditions Description: chemical ablation: osteoblast, chemical treatment by environment: dorsomorphin, chemical treatment by environment: nifurpirinol
| chemical ablation: osteoblast |
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| Name: | chemical ablation |
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| Synonyms: | |
| Definition: | Experimental condition which uses a chemical to ablate an anatomical structure or cell. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000169] |
| Name: | osteoblast |
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| Synonyms: | osteoblasts |
| Definition: | A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. |
| Ontology: | Anatomy Ontology [ZFA:0009031] |
| chemical treatment by environment: dorsomorphin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | dorsomorphin |
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| Synonyms: | 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, compound C |
| Definition: | A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. |
| Ontology: | ChEBI [CHEBI:78510] ( EBI ) |
| chemical treatment by environment: nifurpirinol |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | nifurpirinol |
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| Synonyms: | furanace, furpirinol, furpyrinol, prefuran |
| Definition: | |
| Ontology: | ChEBI [CHEBI:135000] ( EBI ) |
| Publication: | McDonald et al., 2021 |
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