| ZFIN ID: ZDB-EXP-180507-4 |
Experiment Conditions Description: chemical treatment by environment: aristolochic acid A, chemical treatment by environment: empagliflozin
| chemical treatment by environment: aristolochic acid A |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | aristolochic acid A |
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| Synonyms: | 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid, 8-methoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, 8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, Aristolochic acid, aristolochic acid A, Aristolochic acid I, aristolochic acid-I, aristolochin |
| Definition: | An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. |
| Ontology: | ChEBI [CHEBI:2825] ( EBI ) |
| chemical treatment by environment: empagliflozin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | empagliflozin |
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| Synonyms: | (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol, (1S)-1,5-anhydro-1-C-{4-chloro-3-((4-{((3S)-oxolan-3-yl)oxy}phenyl)methyl)phenyl}-D-glucitol, 1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene, BI 10773, BI-10773, BI10773, empagliflozin, JARDIANCE |
| Definition: | A C-glycosyl compound consisting of a beta-glucosyl residue having a (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl group at the anomeric centre. A sodium-glucose co-transporter 2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. |
| Ontology: | ChEBI [CHEBI:82720] ( EBI ) |
| Publication: | Shi et al., 2017 |
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