aristolochic acid A

Term ID

CHEBI:2825

Synonyms

• 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid
• 8-methoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
• 8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid
• 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
• Aristolochic acid
• aristolochic acid A
• Aristolochic acid I
• aristolochic acid-I
• aristolochin

Definition

An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.

References

• CAS:313-67-7
• KEGG:C08469
• KNApSAcK:C00001526
• KNApSAcK:C00027516
• LINCS:LSM-2373
• PMID:21558304
• PMID:21719716
• PMID:22071594
• PMID:22118289
• PMID:22126455
• PMID:22245565
• PMID:22373701
• Reaxys:345159
• Wikipedia:Aristolochic_acid

Ontology

ChEBI  ( EBI )

Resources

CTD