PUBLICATION

WNT5 is required for tail formation in the zebrafish embryo

Authors
Rauch, G.-J., Hammerschmidt, M., Blader, P., Schauerte, H.E., Strähle, U., Ingham, P.W., McMahon, A.P. and Haffter, P.
ID
ZDB-PUB-980520-2
Date
1997
Source
Cold Spring Harbor symposia on quantitative biology   62: 227-233 (Abstract)
Registered Authors
Blader, Patrick, Haffter, Pascal, Hammerschmidt, Matthias, Ingham, Philip, McMahon, Andrew, Rauch, Gerd-Jörg, Schauerte, Heike, Strähle, Uwe
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Body Patterning*
  • Embryo, Nonmammalian/physiology*
  • Embryonic Induction*
  • Exons
  • Genetic Linkage
  • Molecular Sequence Data
  • Multigene Family
  • Plant Proteins/chemistry
  • Plant Proteins/genetics
  • Plant Proteins/physiology
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Tail
  • Zebrafish/genetics*
  • Zebrafish/physiology*
(all 18)
PubMed
9598355
Abstract
Intercellular signaling molecules, such as those encoded by the Wnt gene family, have a fundamental role in various aspects of pattern formation in the developing embryo. The zebrafish wnt5 gene encodes a member of a subfamily of Wnt molecules thought to be involved in modulating cell behavior during vertebrate development. Here, we show that the zebrafish pipetail gene is identical to wnt5. The pipetail mutant phenotype is characterized by defects in tail formation and impaired maturation of cells that contribute to cartilaginous elements of the head skeleton. This suggests a major role for wnt5 in morphogenetic processes underlying tail outgrowth and cartilaginous differentiation in the head. To investigate the function of maternally derived wnt5 mRNA, we generated females that were homozygous for pipetail. The lack of a maternal effect phenotype in the progeny of these females suggests that no obvious function for the maternal wnt5 expression can be deduced.
Genes / Markers
Figures
No images available
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
ta98
    Point Mutation
    tc271b
      Unknown
      te1c
        Unknown
        th278
          Point Mutation
          ti265
            Point Mutation
            1 - 5 of 5
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            Human Disease / Model
            No data available
            Sequence Targeting Reagents
            No data available
            Fish
            Antibodies
            Orthology
            Engineered Foreign Genes
            No data available
            Mapping