Person
Ingham, Philip
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Biography and Research Interest
1977 BA (Hons) in Genetics, Cambridge University U.K.
1981 D.Phil Developmental Genetics University of Sussex, UK
1981-2 Royal Society European Exchange Postdoctoral fellow, LGME, Strasbourg, France
1982-85 Post doctoral research assistant, Imperial Cancer Research Fund, Mill Hill, U.K.
1986 Research Scientist, MRC Laboratory of Molecular Biology, Cambridge, U.K.
1986-94 Staff Scientist, Imperial Cancer Research Fund, Oxford, U.K.
1994-96 Principal Scientist, Imperial Cancer Research Fund, London, U.K.
1996-09 Professor of Developmental Genetics, University of Sheffield, U.K.
2009 -11 Deputy Director, Institute of Molecular & Cell Biology, Singapore
2013-2016 Vice Dean Research, Lee Kong Chian School of Medicine, Singapore
2016-2018 Director, Living Systems Institute, University of Exeter, UK
2018 - Toh Kian Chui Distinguished Professor, Lee Kong Chian School of Medicine, Singapore
My early research focused on the genetic analysis of development in Drosophila. I identified and characterised the trithorax and super sex combs loci, applied the technique of in situ hybridisation to the analysis of the gap and pair rule gene hierarchy, cloned the patched and smoothened genes and elucidated their role, together with that of ci, fused and cos-2, in the Hh signal transduction pathway. Since the early 1990s my lab has used similar approaches in the analysis of zebrafish development. In 1993 we idenitifed three members of the Hh family (In collaboration with Andy McMahon and Cliff Tabin) - a major focus of our subsequent research has been the deployment of Hh signalling in muscle cell type specification. Current interests include the differentiaition and regeneration of skeletal muscle, as well as the evolution of signalling pathways and transcritpional control networks.
1981 D.Phil Developmental Genetics University of Sussex, UK
1981-2 Royal Society European Exchange Postdoctoral fellow, LGME, Strasbourg, France
1982-85 Post doctoral research assistant, Imperial Cancer Research Fund, Mill Hill, U.K.
1986 Research Scientist, MRC Laboratory of Molecular Biology, Cambridge, U.K.
1986-94 Staff Scientist, Imperial Cancer Research Fund, Oxford, U.K.
1994-96 Principal Scientist, Imperial Cancer Research Fund, London, U.K.
1996-09 Professor of Developmental Genetics, University of Sheffield, U.K.
2009 -11 Deputy Director, Institute of Molecular & Cell Biology, Singapore
2013-2016 Vice Dean Research, Lee Kong Chian School of Medicine, Singapore
2016-2018 Director, Living Systems Institute, University of Exeter, UK
2018 - Toh Kian Chui Distinguished Professor, Lee Kong Chian School of Medicine, Singapore
My early research focused on the genetic analysis of development in Drosophila. I identified and characterised the trithorax and super sex combs loci, applied the technique of in situ hybridisation to the analysis of the gap and pair rule gene hierarchy, cloned the patched and smoothened genes and elucidated their role, together with that of ci, fused and cos-2, in the Hh signal transduction pathway. Since the early 1990s my lab has used similar approaches in the analysis of zebrafish development. In 1993 we idenitifed three members of the Hh family (In collaboration with Andy McMahon and Cliff Tabin) - a major focus of our subsequent research has been the deployment of Hh signalling in muscle cell type specification. Current interests include the differentiaition and regeneration of skeletal muscle, as well as the evolution of signalling pathways and transcritpional control networks.
Non-Zebrafish Publications
Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW. (2004) Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.Mech Dev. 121(6):507-18Needham AJ, Kibart M, Crossley H, Ingham PW, Foster SJ. (2004) Drosophila melanogaster as a model host for Staphylococcus aureus infection. Microbiology. 150:2347-55.
Thomas C, Ingham PW. (2003) Hedgehog Signaling in the Drosophila Eye and Head. An analysis of the effects of different patched trans-heterozygotes. Genetics 165:1915-28
Shivdasani AA, Ingham PW. (2003) Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis. Curr Biol. 13:2065-72
McMahon AP., Ingham PW, & Tabin C. (2003) Development Roles and Clinical Significance of Hedgehog signaling. Current Topics in Developmental Biology 5: 1-114
Glise, B. Jones, DL & Ingham, PW (2002) Modulation of Hedgehog target gene expression by Notch and Wingless during Drosophila wing development. Developmental Biology 248: 93-106
Ingham PW, McMahon AP. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes & Devl 15: 3059-87.
Ingham PW. (2001) Hedgehog signaling: a tale of two lipids. Science. 294:1879-81.
Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW.
Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.Curr Biol. 2001 Apr 17;11(8):608-13.
Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM.Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.Curr Biol. 2000 Oct 19;10(20):1315-8.
Placzek M, Ingham PW. Developmental genetics in Sheffield: a meeting point for Hedgehog researchers. Int J Dev Biol. 2000;44(1 Spec No):65-72.
Cunliffe VT, Ingham PW. Switching on the notochord. Genes Dev. 1999 Jul 1;13(13):1643-6.
Lewis KE, Drossopoulou G, Paton IR, Morrice DR, Robertson KE, Burt DW, Ingham PW, Tickle C. Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development. 1999 Jun;126(11):2397-407.
Ingham PW. Boning up on Hedgehog's movements. Nature. 1998 Jul 2;394(6688):16-7.
Ingham PW. trithorax and the regulation of homeotic gene expression in Drosophila: a historical perspective. Int J Dev Biol. 1998;42(3 Spec No):423-9.
Ingham PW.Transducing Hedgehog: the story so far.EMBO J. 1998 Jul 1;17(13):3505-11.
Currie PD, Ingham PW.The generation and interpretation of positional information within the vertebrate myotome. Mech Dev. 1998 Apr;73(1):3-21.
Quirk J, van den Heuvel M, Henrique D, Marigo V, Jones TA, Tabin C, Ingham PW.The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development.Cold Spring Harb Symp Quant Biol. 1997;62:217-26.
Ingham PW.The patched gene in development and cancer. Curr Opin Genet Dev. 1998 Feb;8(1):88-94.
Ingham PW. Has the quest for a Wnt receptor finally frizzled out?
Trends Genet. 1996 Oct;12(10):382-4.
Forbes AJ, Spradling AC, Ingham PW, Lin H.The role of segment polarity genes during early oogenesis in Drosophila.Development. 1996 Oct;122(10):3283-94.
Alexandre C, Jacinto A, Ingham PW.Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 1996 Aug 15;10(16):2003-13.
van den Heuvel M, Ingham PW.smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.Nature. 1996 Aug 8;382(6591):547-51.
Forbes AJ, Lin H, Ingham PW, Spradling AC.hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila.Development. 1996 Apr;122(4):1125-35.
Ingham PW.Signalling by hedgehog family proteins in Drosophila and vertebrate development. Curr Opin Genet Dev. 1995 Aug;5(4):492-8.
Fietz MJ, Jacinto A, Taylor AM, Alexandre C, Ingham PW.Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.Curr Biol. 1995 Jun 1;5(6):643-50.
Concordet JP, Ingham P.Developmental biology. Patterning goes sonic.
Nature. 1995 May 25;375(6529):279-80.
Ingham PW, Fietz MJ.Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr Biol. 1995 Apr 1;5(4):432-40.
Ingham P.Signal transduction. Dorsal developments.Nature. 1994 Dec 8;372(6506):500-1.
Paroush Z, Finley RL Jr, Kidd T, Wainwright SM, Ingham PW, Brent R, Ish-Horowicz D.Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins.Cell. 1994 Dec 2;79(5):805-15.
Ingham PW. Pattern formation. Hedgehog points the way.Curr Biol. 1994 Apr 1;4(4):347-50. Review.
Fietz MJ, Concordet JP, Barbosa R, Johnson R, Krauss S, McMahon AP, Tabin C, Ingham PW.The hedgehog gene family in Drosophila and vertebrate development. Dev Suppl. 1994;:43-51.
Ingham PW. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.Nature. 1993 Dec 9;366(6455):560-2.
Taylor AM, Nakano Y, Mohler J, Ingham PW.Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech Dev. 1993 Jul;42(1-2):89-96.
Ingham PW, Hidalgo A. Regulation of wingless transcription in the Drosophila embryo.Development. 1993 Jan;117(1):283-91.
Forbes AJ, Nakano Y, Taylor AM, Ingham PW. Genetic analysis of hedgehog signalling in the Drosophila embryo.Dev Suppl. 1993;:115-24.
Eisenberg LM, Ingham PW, Brown AM.Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene distal-less.Dev Biol. 1992 Nov;154(1):73-83.
Holland P, Ingham P, Krauss S.Development and evolution. Mice and flies head to head.Nature. 1992 Aug 20;358(6388):627-8.
Ingham PW, Martinez Arias A. Boundaries and fields in early embryos.
Cell. 1992 Jan 24;68(2):221-35.
Ingham PW, Taylor AM, Nakano Y. Role of the Drosophila patched gene in positional signalling.Nature. 1991 Sep 12;353(6340):184-7.
Ingham PW.Segment polarity genes and cell patterning within the Drosophila body segment.Curr Opin Genet Dev. 1991 Aug;1(2):261-7.
Hidalgo A, Ingham P.Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched.Development. 1990 Sep;110(1):291-301.
Phillips RG, Roberts IJ, Ingham PW, Whittle JR. The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs. Development. 1990 Sep;110(1):105-14.