PUBLICATION
Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses
- Authors
- Morizet, D., Foucher, I., Alunni, A., Bally-Cuif, L.
- ID
- ZDB-PUB-240418-2
- Date
- 2024
- Source
- Nature communications 15: 33063306 (Journal)
- Registered Authors
- Alunni, Alessandro, Bally-Cuif, Laure, Foucher, Isabelle, Morizet, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Astrocytes*
- Gene Expression Profiling
- Humans
- Mammals
- Neurogenesis/physiology
- Neuroglia/physiology
- Zebrafish*
- PubMed
- 38632253 Full text @ Nat. Commun.
Citation
Morizet, D., Foucher, I., Alunni, A., Bally-Cuif, L. (2024) Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses. Nature communications. 15:33063306.
Abstract
Macroglia fulfill essential functions in the adult vertebrate brain, producing and maintaining neurons and regulating neuronal communication. However, we still know little about their emergence and diversification. We used the zebrafish D. rerio as a distant vertebrate model with moderate glial diversity as anchor to reanalyze datasets covering over 600 million years of evolution. We identify core features of adult neurogenesis and innovations in the mammalian lineage with a potential link to the rarity of radial glia-like cells in adult humans. Our results also suggest that functions associated with astrocytes originated in a multifunctional cell type fulfilling both neural stem cell and astrocytic functions before these diverged. Finally, we identify conserved elements of macroglial cell identity and function and their time of emergence during evolution.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping