PUBLICATION
Stress resilience is established during development and is regulated by complement factors
- Authors
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G.
- ID
- ZDB-PUB-230115-2
- Date
- 2023
- Source
- Cell Reports 42: 111973111973 (Journal)
- Registered Authors
- Anbalagan, Savani, Gliksberg, Michael, Levkowitz, Gil, Swaminathan, Amrutha
- Keywords
- CP: Neuroscience, individual variability, innate immunity, neurodevelopment, neuroimmune, personality traits, stress coping, zebrafish
- Datasets
- GEO:GSE193433
- MeSH Terms
-
- Animals
- Complement Activation
- Resilience, Psychological*
- Stress, Psychological
- Zebrafish
- PubMed
- 36640352 Full text @ Cell Rep.
Citation
Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973.
Abstract
Individuals in a population respond differently to stressful situations. While resilient individuals recover efficiently, others are susceptible to the same stressors. However, it remains challenging to determine if resilience is established as a trait during development or acquired later in life. Using a behavioral paradigm in zebrafish larvae, we show that resilience is a stable and heritable trait, which is determined and exhibited early in life. Resilient larvae show unique stress-induced transcriptional response, and larvae with mutations in resilience-associated genes, such as neuropeptide Y and miR218, are less resilient. Transcriptome analysis shows that resilient larvae downregulate multiple factors of the innate immune complement cascade in response to stress. Perturbation of critical complement factors leads to an increase in resilience. We conclude that resilience is established as a stable trait early during development and that neuropeptides and the complement pathway play positive and negative roles in determining resilience, respectively.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping