PUBLICATION

A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation

Authors
Pei, W., Xu, L., Chen, Z., Slevin, C.C., Pettie, K.P., Wincovitch, S., NISC Comparative Sequencing Program, Burgess, S.M.
ID
ZDB-PUB-200403-198
Date
2020
Source
NPJ Regenerative medicine   5: 6 (Journal)
Registered Authors
Burgess, Shawn, Pei, Wuhong, Xu, Lisha
Keywords
Genetics, Regeneration
MeSH Terms
none
PubMed
32218991 Full text @ NPJ Regen Med
Abstract
Spinal muscular atrophy (SMA) is the most common genetic disease in children. SMA is generally caused by mutations in the gene SMN1. The survival of motor neurons (SMN) complex consists of SMN1, Gemins (2-8), and Strap/Unrip. We previously demonstrated smn1 and gemin5 inhibited tissue regeneration in zebrafish. Here we investigated each individual SMN complex member and identified gemin3 as another regeneration-essential gene. These three genes are likely pan-regenerative, since they affect the regeneration of hair cells, liver, and caudal fin. RNA-Seq analysis reveals that smn1, gemin3, and gemin5 are linked to a common set of genetic pathways, including the tp53 and ErbB pathways. Additional studies indicated all three genes facilitate regeneration by inhibiting the ErbB pathway, thereby allowing cell proliferation in the injured neuromasts. This study provides a new understanding of the SMN complex and a potential etiology for SMA and potentially other rare unidentified genetic diseases with similar symptoms.
Genes / Markers
Figures
Figure Gallery (8 images)
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
fh229
    		Point Mutation
    hg80
      		Small Deletion
      hg81
        		Small Deletion
        hg91
          		Small Deletion
          hg104
            		Indel
            hg105
              		Indel
              hg106
                		Small Deletion
                hg107
                  		Small Deletion
                  hg108
                    		Small Deletion
                    hg109
                      		Insertion
                      1 - 10 of 24
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                      Human Disease / Model
                      No data available
                      Sequence Targeting Reagents
                      Fish
                      Antibodies
                      Orthology
                      Engineered Foreign Genes
                      Marker Marker Type Name
                      CFPEFGCFP
                      EGFPEFGEGFP
                      GFPEFGGFP
                      NTREFGNTR
                      TomatoEFGTomato
                      1 - 5 of 5
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                      Mapping
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                      Citation
                      Pei, W., Xu, L., Chen, Z., Slevin, C.C., Pettie, K.P., Wincovitch, S., NISC Comparative Sequencing Program, Burgess, S.M. (2020) A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation. NPJ Regenerative medicine. 5:6.