PUBLICATION

Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)

Authors
Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M.
ID
ZDB-PUB-140611-5
Date
2015
Source
Veterinary Pathology   52(2): 388-92 (Journal)
Registered Authors
Murray, Katy, Spitsbergen, Jan
Keywords
chordomas, intestinal, vertebral, zebrafish
MeSH Terms
  • Animals
  • Chordoma/pathology
  • Chordoma/veterinary*
  • Female
  • Fish Diseases/pathology*
  • Intestinal Neoplasms/pathology
  • Intestinal Neoplasms/veterinary*
  • Male
  • Spinal Neoplasms/pathology
  • Spinal Neoplasms/veterinary*
  • Zebrafish
(all 11)
PubMed
24913269 Full text @ Vet. Pathol.
Abstract
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.
Genes / Markers
Marker Marker Type Name
gja5bGENEgap junction protein, alpha 5b
kcnk5bGENEpotassium channel, subfamily K, member 5b
lofGENElong fin
lratb.1GENElecithin retinol acyltransferase b, tandem duplicate 1
notoGENEnotochord homeobox
slc25a37GENEsolute carrier family 25 member 37
tbxtaGENET-box transcription factor Ta
tp53GENEtumor protein p53
1 - 8 of 8
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Figures
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Expression
Phenotype
Fish Conditions Stage Phenotype Figure
SPF 5-Dchemical treatment: dibenzo[a,l]pyreneAdult
SPF 5-Dchemical treatment: N-nitrosodiethylamineAdult
SPF 5-Dchemical treatment: N-nitrosodiethylamineAdult
SPF 5-Dchemical treatment: N-nitrosodiethylamineAdult
SPF 5-Dchemical treatment: N-nitrosodiethylamineAdult
gja5bt1; loft2 (TL)standard conditionsAdult
kcnk5bty86d (AB/TU)standard conditionsAdult
noton1; tbxtab195standard conditionsAdult
slc25a37b333/+ (AB)standard conditionsAdult
slc25a37b333/+ (AB)standard conditionsAdult
1 - 10 of 11
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
b195
    		Insertion
    b333
      		Small Deletion
      n1
        		Small Deletion
        t1
          		Point Mutation
          t2
            		Unknown
            ty86d
              		Point Mutation
              zdf1
                		Point Mutation
                1 - 7 of 7
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                Human Disease / Model
                No data available
                Sequence Targeting Reagents
                No data available
                Fish
                Antibodies
                Orthology
                Engineered Foreign Genes
                No data available
                Mapping
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                Citation
                Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M. (2015) Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). Veterinary Pathology. 52(2):388-92.