PUBLICATION
Identification and expression of soul/p22HBP genes in zebrafish
- Authors
- Fortunato, A.E., Langellotto, F., and Sordino, P.
- ID
- ZDB-PUB-110429-8
- Date
- 2011
- Source
- Gene expression patterns : GEP 11(5-6): 360-369 (Journal)
- Registered Authors
- Sordino, Paolo
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Carrier Proteins/genetics*
- Gene Expression Regulation, Developmental*
- Hemeproteins/genetics*
- In Situ Hybridization
- Molecular Sequence Data
- Phylogeny
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/metabolism
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- PubMed
- 21440679 Full text @ Gene Expr. Patterns
Citation
Fortunato, A.E., Langellotto, F., and Sordino, P. (2011) Identification and expression of soul/p22HBP genes in zebrafish. Gene expression patterns : GEP. 11(5-6):360-369.
Abstract
The SOUL/p22HBP family is an evolutionarily ancient group of heme binding proteins with a main function as cytosolic buffer against tetrapyrrole accumulation. Structural and biochemical evidence suggest specialized roles in blood formation, necrotic cell death and chemotaxis. To date, nothing is known about the precise activity and expression patterns of this class of heme binding proteins during development. The zebrafish genome possesses five soul genes belonging to two subgroups, and no p22HBP orthologous gene. Here, spatial and temporal expression patterns are reported for zebrafish soul1, soul2 and soul4 genes. All three soul genes are maternally transcribed, and their zygotic expression takes place in unique (heart, pharynx, yolk syncytial layer, brain, eyes, lateral line) and overlapping (pronephros, pituitary gland, olfactory and otic vesicle) regions of the zebrafish embryo. Our study constitutes the first detailed analysis of soul gene expression in metazoan development, and provides the basis to understand the genetics of tetrapyrrole metabolism in a wide range of embryonic processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping