PUBLICATION
Analysis of origin and growth of the thyroid gland in zebrafish
- Authors
- Alt, B., Reibe, S., Feitosa, N.M., Elsalini, O.A., Wendl, T., and Rohr, K.B.
- ID
- ZDB-PUB-060517-11
- Date
- 2006
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 235(7): 1872-1883 (Journal)
- Registered Authors
- Alt, Burkhard, Elsalini, Osama, Feitosa, Natalia Martins, Reibe, Saskia, Rohr, Klaus, Wendl, Thomas
- Keywords
- thyroglobulin, sodium/iodide symporter, calcitonin, cathepsin b, fate map, tsh, TARAM-A, goitrogen, endoderm
- MeSH Terms
-
- Animals
- Calcitonin/metabolism
- Cell Differentiation
- Cell Lineage/physiology
- Embryo, Nonmammalian/embryology
- Endoderm/cytology
- Endoderm/metabolism
- Larva/growth & development
- Larva/metabolism
- Morphogenesis
- Thyroid Gland/embryology
- Thyroid Gland/growth & development*
- Thyroid Gland/metabolism
- Zebrafish/embryology*
- Zebrafish/growth & development*
- Zebrafish Proteins/biosynthesis
- PubMed
- 16680726 Full text @ Dev. Dyn.
Citation
Alt, B., Reibe, S., Feitosa, N.M., Elsalini, O.A., Wendl, T., and Rohr, K.B. (2006) Analysis of origin and growth of the thyroid gland in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(7):1872-1883.
Abstract
The zebrafish thyroid gland shows a unique pattern of growth as a differentiated endocrine gland. Here, we analyze the onset of differentiation, the contribution of lineages, and the mode of growth of this gland. The expression of genes involved in hormone production and the establishment of epithelial polarity show that differentiation into a first thyroid follicle takes place early during embryonic development. Thyroid follicular tissue then grows along the pharyngeal midline, initially independently of thyroid stimulating hormone. Lineage analysis reveals that thyroid follicle cells are exclusively recruited from the pharyngeal endoderm. The ultimobranchial bodies that merge with the thyroid in mammals form separate glands in zebrafish as visualized by calcitonin precursor gene expression. Mosaic analysis suggests that the first thyroid follicle differentiating at 55 hours postfertilization corresponds later to the most anterior follicle and that new follicles are added caudally.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping