PUBLICATION
Gonadotropin-releasing hormone (gnrh) cells arise from cranial neural crest and adenohypophyseal regions of the neural plate in the zebrafish, Danio rerio
- Authors
- Whitlock, K.E., Wolf, C.D., and Boyce, M.L.
- ID
- ZDB-PUB-030514-3
- Date
- 2003
- Source
- Developmental Biology 257(1): 140-152 (Journal)
- Registered Authors
- Boyce, Mayely, Whitlock, Kate, Wolf, Catherine
- Keywords
- none
- MeSH Terms
-
- Animals
- Carbocyanines
- Gonadotropin-Releasing Hormone/metabolism*
- Head/embryology
- Immunohistochemistry
- Mutation
- Neural Crest/metabolism*
- Pituitary Gland, Anterior/embryology
- Pituitary Gland, Anterior/metabolism
- Staining and Labeling
- Transcription Factors/genetics
- Transcription Factors/metabolism
- Zebrafish/embryology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 12710963 Full text @ Dev. Biol.
Citation
Whitlock, K.E., Wolf, C.D., and Boyce, M.L. (2003) Gonadotropin-releasing hormone (gnrh) cells arise from cranial neural crest and adenohypophyseal regions of the neural plate in the zebrafish, Danio rerio. Developmental Biology. 257(1):140-152.
Abstract
The olfactory placodes generate the primary sensory neurons of the olfactory sensory system. Additionally, the olfactory placodes have been proposed to generate a class of neuroendocrine cells containing gonadotropin-releasing hormone (GnRH). GnRH is a multifunctional decapeptide essential for the development of secondary sex characteristics in vertebrates as well as a neuromodulator within the central nervous system. Here, we show that endocrine and neuromodulatory GnRH cells arise from two separate, nonolfactory regions in the developing neural plate. Specifically, the neuromodulatory GnRH cells of the terminal nerve arise from the cranial neural crest, and the endocrine GnRH cells of the hypothalamus arise from the adenohypophyseal region of the developing anterior neural plate. Our findings are consistent with cell types generated by the adenohypophysis, a source of endocrine tissue in vertebrate animals, and by neural crest, a source of cells contributing to the cranial nerves. The adenohypophysis arises from a region of the anterior neural plate flanked by the olfactory placode fields at early stages of development, and premigratory cranial neural crest lies adjacent to the caudal edge of the olfactory placode domain [Development 127 (2000), 3645]. Thus, the GnRH cells arise from tissue closely associated with the developing olfactory placode, and their different developmental origins reflect their different functional roles in the adult animal.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping