PUBLICATION

Odorant receptor gene regulation: implications from genomic organization

Authors
Kratz, E., Dugas, J.C., and Ngai, J.
ID
ZDB-PUB-020111-1
Date
2002
Source
Trends in genetics : TIG   18(1): 29-34 (Journal)
Registered Authors
Kratz, Erica, Ngai, John
Keywords
none
MeSH Terms
  • Alleles
  • Animals
  • Biological Evolution
  • Gene Expression Regulation
  • Genome
  • Humans
  • Mice
  • Models, Genetic
  • Multigene Family
  • Olfactory Receptor Neurons/metabolism
  • Receptors, Odorant/genetics*
  • Zebrafish/genetics
(all 12)
PubMed
11750698 Full text @ Trends Genet.
Abstract
Odorant receptor genes comprise the largest known family of G-protein-coupled receptors in vertebrates. These receptor genes are tightly clustered in the genomes of every vertebrate organism investigated, including zebrafish, mice and humans, and they appear to have expanded and duplicated throughout evolution. In a mechanism that has yet to be elucidated, each olfactory neuron expresses a single receptor gene. This highly restricted expression pattern underlies the ability to distinguish between a wide variety of odorants. Here, we address the evolutionary expansion of odorant receptor genes and the role genomic organization of these genes might have in their tightly regulated expression.
Genes / Markers
Marker Marker Type Name
or2.12pGENEPodorant receptor, family 2, member 12, pseudogene
or2.13pGENEPodorant receptor, family 2, member 13, pseudogene
or30bt1GENEodorant receptor family 30, subfamily BT, member 1
or30bt2GENEodorant receptor family 30, subfamily BT, member 2
or30bt4GENEodorant receptor, family 30, subfamily BT, member 4
or30bt5GENEodorant receptor, family 30, subfamily BT, member 5
or30bu2GENEodorant receptor, family 30, subfamily BU, member 2
or30bw1GENEodorant receptor, family 30, subfamily BW, member 1
or30bx1GENEodorant receptor, family 30, subfamily BX, member 1
or30by1GENEodorant receptor, family 30, subfamily BY, member 1
1 - 10 of 34
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Figures
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Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
No data available
Fish
Antibodies
Orthology
Engineered Foreign Genes
No data available
Mapping
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Citation
Kratz, E., Dugas, J.C., and Ngai, J. (2002) Odorant receptor gene regulation: implications from genomic organization. Trends in genetics : TIG. 18(1):29-34.