ZFIN Morpholino: MO1-heg1

Target Location

Genome Build: GRCz11Chromosome: 9

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-heg1

Expressed Gene	Anatomy	Figures
cdh5	blood vessel endothelial cell cell-cell junction	Fig. S9 from Kleaveland et al., 2009
myb	ventral wall of dorsal aorta	Fig. 3 from Wang et al., 2011
rag1	(not) thymus	Fig. 3 from Wang et al., 2011
rasip1	dorsal longitudinal anastomotic vessel cell-cell junction	Fig. 8. from Lee et al., 2021
runx1	ventral wall of dorsal aorta	Fig. 3 from Wang et al., 2011

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Phenotype

Phenotype resulting from MO1-heg1

Phenotype	Fish	Figures
blood vasculature obstructed, abnormal	y1Tg + MO1-heg1	Fig. 4 from Kleaveland et al., 2009
dorsal longitudinal anastomotic vessel cell-cell junction rasip1 expression decreased amount, abnormal	s843Tg + MO1-heg1	Fig. 8. from Lee et al., 2021
dorsal longitudinal anastomotic vessel cell-cell junction rasip1 expression mislocalised, abnormal	s843Tg + MO1-heg1	Fig. 8. from Lee et al., 2021
heart dilated, abnormal	y1Tg + MO1-heg1	Fig. 4 from Kleaveland et al., 2009
heart edematous, abnormal	y1Tg + MO1-heg1	Fig. 4 from Kleaveland et al., 2009

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Phenotype of all Fish created by or utilizing MO1-heg1

Phenotype	Fish	Conditions	Figures
heart increased size, abnormal	WT + MO1-heg1	standard conditions	Fig. 6 from Serluca, 2008
thymus decreased size, abnormal	WT + MO1-heg1	standard conditions	Fig. 3 from Wang et al., 2011
thymus hematopoietic multipotent progenitor cell decreased amount, abnormal	WT + MO1-heg1	standard conditions	Fig. 3 from Wang et al., 2011
pericardium edematous, abnormal	WT + MO1-heg1	standard conditions	Fig. 6 from Serluca, 2008
trunk hematopoietic multipotent progenitor cell decreased amount, abnormal	WT + MO1-heg1	standard conditions	Fig. 3 from Wang et al., 2011

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Citations

Include unpublished citations

Lee, M., Betz, C., Yin, J., Paatero, I., Schellinx, N., Carte, A.N., Wilson, C.W., Ye, W., Affolter, M., Belting, H.G. (2021) Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1. Development (Cambridge, England). 148(15):
Donat, S., Lourenço, M., Paolini, A., Otten, C., Renz, M., Abdelilah-Seyfried, S. (2018) Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. eLIFE. 7:e28939
Wang, L., Zhang, P., Wei, Y., Gao, Y., Patient, R., and Liu, F. (2011) A blood flow-dependent klf2a-NO signalling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 118(15):4102-10
Kleaveland, B., Zheng, X., Liu, J.J., Blum, Y., Tung, J.J., Zou, Z., Chen, M., Guo, L., Lu, M.M., Zhou, D., Kitajewski, J., Affolter, M., Ginsberg, M.H., and Kahn, M.L. (2009) Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nature medicine. 15(2):169-176
Ouyang, X., Shestopalov, I.A., Sinha, S., Zheng, G., Pitt, C.L., Li, W.H., Olson, A.J., and Chen, J.K. (2009) Versatile Synthesis and Rational Design of Caged Morpholinos. Journal of the American Chemical Society. 131(37):13255-13269
Serluca, F.C. (2008) Development of the proepicardial organ in the zebrafish. Developmental Biology. 315(1):18-27
Mably, J.D., Mohideen, M.A.P.K., Burns, C.G., Chen, J.-N., and Fishman, M.C. (2003) heart of glass regulates the concentric growth of the heart in zebrafish. Current biology : CB. 13(24):2138-2147

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