Gene

myb

ID

ZDB-GENE-991110-14

Name

v-myb avian myeloblastosis viral oncogene homolog

Symbol

myb Nomenclature History

Previous Names

c-myb
cmyb

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including definitive hemopoiesis; hematopoietic stem cell migration; and regulation of neutrophil differentiation. Localizes to chromatin. Is expressed in several structures, including head; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human MYB (MYB proto-oncogene, transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

475 figures from 238 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu660 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{T-cell acute lymphoblastic leukemia}

Associated With myb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001005	SANT/Myb domain
Domain	IPR012642	Transcription regulator Wos2-domain
Domain	IPR015395	C-myb, C-terminal
Domain	IPR017930	Myb domain
Homologous_superfamily	IPR009057	Homedomain-like superfamily