ZFIN Morpholino: MO1-smarca4a

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-smarca4a

Expressed Gene	Anatomy	Figures
ctnnb1	whole organism	Fig. 10 from Eroglu et al., 2006
egr2b	neural plate presumptive rhombomere 3 presumptive rhombomere 5	Fig. 3 from Eroglu et al., 2006
en2a	(not) midbrain hindbrain boundary neural keel (not) midbrain hindbrain boundary neural plate whole organism	Fig. 3 , Fig. 10 from Eroglu et al., 2006
foxd3	neural crest	Fig. 6 from Eroglu et al., 2006
fzd2	whole organism	Fig. 10 from Eroglu et al., 2006

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Phenotype

Phenotype resulting from MO1-smarca4a

Phenotype	Fish	Figures
cardiac muscle cell decreased amount, abnormal	hsc4Tg + MO1-smarca4a	Fig. 3 from Takeuchi et al., 2011
cell migration involved in heart development decreased rate, abnormal	twu34Tg/+ + MO1-smarca4a	Fig. 3 from Takeuchi et al., 2011
chromatin organization process quality, abnormal	TU + MO1-smarca4a	Fig. S7 from Liu et al., 2018
ear development disrupted, abnormal	WT + MO1-smarca4a	text only from Gregg et al., 2003
fin morphology, abnormal	WT + MO1-smarca4a	text only from Gregg et al., 2003

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Phenotype of all Fish created by or utilizing MO1-smarca4a

Phenotype	Fish	Conditions	Figures
chromatin organization process quality, abnormal	TU + MO1-smarca4a	standard conditions	Fig. S7 from Liu et al., 2018
inner ear morphology, abnormal	WT + MO1-smarca4a	standard conditions	text only from Gregg et al., 2003
ear development disrupted, abnormal	WT + MO1-smarca4a	standard conditions	text only from Gregg et al., 2003
fin morphology, abnormal	WT + MO1-smarca4a	standard conditions	text only from Gregg et al., 2003
melanocyte decreased amount, abnormal	WT + MO1-smarca4a	standard conditions	text only from Gregg et al., 2003

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Citations

Include unpublished citations

Liu, G., Wang, W., Hu, S., Wang, X., Zhang, Y. (2018) Inherited DNA methylation primes the establishment of accessible chromatin during genome activation. Genome research. 28(7):998-1007
Takeuchi, J.K., Lou, X., Alexander, J.M., Sugizaki, H., Delgado-Olguín, P., Holloway, A.K., Mori, A.D., Wylie, J.N., Munson, C., Zhu, Y., Zhou, Y.Q., Yeh, R.F., Henkelman, R.M., Harvey, R.P., Metzger, D., Chambon, P., Stainier, D.Y., Pollard, K.S., Scott, I.C., and Bruneau, B.G. (2011) Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nature communications. 2:187
Mallappa, C., Nasipak, B.T., Etheridge, L., Androphy, E.J., Jones, S.N., Sagerström, C.G., Ohkawa, Y., and Imbalzano, A.N. (2010) Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Molecular and cellular biology. 30(13):3176-3186
Eroglu, B., Wang, G., Tu, N., Sun, X., and Mivechi, N.F. (2006) Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(10):2722-2735
Gregg, R.G., Willer, G.B., Fadool, J.M., Dowling, J.E., and Link, B.A. (2003) Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 100(11):6535-6540

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