ZFIN Morpholino: MO1-bbs1

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-bbs1

Expressed Gene	Anatomy	Figures
axin2	tail bud whole organism	Fig. 2 from Gerdes et al., 2007
c3a.2	whole organism	Fig. 7 from Hostelley et al., 2016
cela1.6	whole organism	Fig. 7, Fig. S3 from Hostelley et al., 2016
chrd	presumptive dorsal mesoderm	Fig. 5, Fig. S3 from Gerdes et al., 2007
ctrb.1	whole organism	Fig. S3 from Hostelley et al., 2016

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Phenotype

Phenotype resulting from MO1-bbs1

Phenotype	Fish	Figures
cell migration involved in gastrulation disrupted, abnormal	WT + MO1-bbs1	Fig. S3 from Zaghloul et al., 2010
convergent extension process quality, abnormal	WT + MO1-bbs1	Fig. 5 from Lindstrand et al., 2014
convergent extension involved in axis elongation disrupted, abnormal	WT + MO1-bbs1	Fig. 1 from Gerdes et al., 2007
convergent extension involved in gastrulation disrupted, abnormal	WT + MO1-bbs1	Fig. 2 from Gerdes et al., 2007
exocrine pancreas decreased area, abnormal	jh1Tg; jh2Tg + MO1-bbs1	Fig. S1 from Lodh et al., 2016

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Phenotype of all Fish created by or utilizing MO1-bbs1

Phenotype	Fish	Conditions	Figures
whole organism snord31.1 expression increased amount, abnormal	TU + MO1-bbs1	standard conditions	Fig. 7 from Hostelley et al., 2016
pancreatic A cell gcga expression decreased amount, abnormal	TU + MO1-bbs1	standard conditions	Fig. 2 from Lodh et al., 2016
whole organism vtg7 expression increased amount, abnormal	TU + MO1-bbs1	standard conditions	Fig. 7 from Hostelley et al., 2016
whole organism ctrl expression increased amount, abnormal	TU + MO1-bbs1	standard conditions	Fig. S3 from Hostelley et al., 2016
whole organism cela1.6 expression increased amount, abnormal	TU + MO1-bbs1	standard conditions	Fig. 7, Fig. S3 from Hostelley et al., 2016

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Citations

Include unpublished citations

Hostelley, T.L., Nesmith, J.E., Larkin, E., Jones, A., Boyes, D., Leitch, C.C., Fontaine, M., Zaghloul, N.A. (2021) Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems. Biology Open. 10(6):
Castro-Sánchez, S., Suarez-Bregua, P., Novas, R., Álvarez-Satta, M., Badano, J.L., Rotllant, J., Valverde, D. (2019) Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model. Scientific Reports. 9:12936
Hostelley, T.L., Lodh, S., Zaghloul, N.A. (2016) Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes. BMC Genomics. 17:318
Lodh, S., Hostelley, T.L., Leitch, C.C., O'Hare, E.A., Zaghloul, N.A. (2016) Differential effects on β-cell mass by disruption of Bardet-Biedl Syndrome or Alstrom Syndrome genes. Human molecular genetics. 25(1):57-68
Leitch, C.C., Lodh, S., Prieto-Echagüe, V., Badano, J.L., Zaghloul, N.A. (2014) Basal body proteins regulate Notch signaling via endosomal trafficking. Journal of Cell Science. 127(Pt 11):2407-19
Lindstrand, A., Davis, E.E., Carvalho, C.M., Pehlivan, D., Willer, J.R., Tsai, I.C., Ramanathan, S., Zuppan, C., Sabo, A., Muzny, D., Gibbs, R., Liu, P., Lewis, R.A., Banin, E., Lupski, J.R., Clark, R., Katsanis, N. (2014) Recurrent CNVs and SNVs at the NPHP1 Locus Contribute Pathogenic Alleles to Bardet-Biedl Syndrome. American journal of human genetics. 94:745-54
Putoux, A., Thomas, S., Coene, K.L.M., Davis, E.E., Alanay, Y., Ogur, G., Uz, E., Buzas, D., Gomes, C., Patrier, S., Bennett, C.L., Elkhartoufi, N., Saint Frison, M.H., Rigonnot, L., Joye, N., Pruvost, S., Utine, G.E., Boduroglu, K., Nitschke, P., Fertitta, L., Thauvin-Robinet, C., Munnich, A., Cormier-Daire, V., Hennekam, R., Colin, E., Akarsu, N.A., Bole-Feysot, C., Cagnard, N., Schmitt, A., Goudin, N., Lyonnet, S., Encha-Razavi, F., Siffroi, J.P., Winey, M., Katsanis, N., Gonzales, M., Vekemans, M., Beales, P.L., and Attie-Bitach, T. (2011) KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. Nature Genetics. 43:601-606
Zaghloul, N.A., Liu, Y., Gerdes, J.M., Gascue, C., Oh, E.C., Leitch, C.C., Bromberg, Y., Binkley, J., Leibel, R.L., Sidow, A., Badano, J.L., and Katsanis, N. (2010) Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107(23):10602-10607
Gerdes, J.M., Liu, Y., Zaghloul, N.A., Leitch, C.C., Lawson, S.S., Kato, M., Beachy, P.A., Beales, P.L., Demartino, G.N., Fisher, S., Badano, J.L., and Katsanis, N. (2007) Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nature Genetics. 39(11):1350-1360
Badano, J.L., Leitch, C.C., Ansley, S.J., May-Simera, H., Lawson, S., Lewis, R.A., Beales, P.L., Dietz, H.C., Fisher, S., and Katsanis, N. (2006) Dissection of epistasis in oligogenic Bardet-Biedl syndrome. Nature. 439(7074):326-30

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