ZFIN Morpholino: MO2-tbx16

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-tbx16

Expressed Gene	Anatomy	Figures
dand5	Kupffer's vesicle	Fig. 1 from Gourronc et al., 2007
nphs1	pronephric glomerulus	Fig. 8 from Huang et al., 2013
nphs2	pronephric glomerulus	Fig. 8 from Huang et al., 2013
slc20a1a	pronephric proximal convoluted tubule	Fig. 8 from Huang et al., 2013
spaw	(not) Kupffer's vesicle lateral plate mesoderm	Fig. 1 from Gourronc et al., 2007

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Phenotype

Phenotype resulting from MO2-tbx16

No data available

Phenotype of all Fish created by or utilizing MO2-tbx16

Phenotype	Fish	Conditions	Figures
mesodermal cell migration disrupted, abnormal	WT + MO1-tbx16 + MO2-tbx16	standard conditions	Fig. 3 from Row et al., 2011
mesoderm morphology, abnormal	WT + MO1-tbx16 + MO2-tbx16	standard conditions	Fig. 2 from Row et al., 2011
mesodermal to mesenchymal transition involved in gastrulation disrupted, abnormal	WT + MO1-tbx16 + MO2-tbx16	standard conditions	Fig. 2 from Row et al., 2011
mesoderm decreased amount, abnormal	WT + MO1-tbx16 + MO2-tbx16	standard conditions	Fig. 3 from Araya et al., 2014
mesodermal cell spatial pattern, abnormal	WT + MO1-tbx16 + MO2-tbx16	standard conditions	Fig. 3 from Row et al., 2011

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Citations

Include unpublished citations

Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
Kinney, B.A., Al Anber, A., Row, R.H., Tseng, Y.J., Weidmann, M.D., Knaut, H., Martin, B.L. (2020) Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition. Cell Reports. 33:108311
Bouldin, C.M., Manning, A.J., Peng, Y.H., Farr, G.H., Hung, K.L., Dong, A., Kimelman, D. (2015) Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development (Cambridge, England). 142:2499-507
Manning, A.J., Kimelman, D. (2015) Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors. Developmental Biology. 406(2):172-85
Araya, C., Tawk, M., Girdler, G.C., Costa, M., Carmona-Fontaine, C., and Clarke, J.D. (2014) Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo. Neural Development. 9(1):9
Huang, C.J., Wilson, V., Pennings, S., MacRae, C.A., and Mullins, J. (2013) Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Developmental Biology. 384(2):290-300
Row, R.H., Maître, J.L., Martin, B.L., Stockinger, P., Heisenberg, C.P., and Kimelman, D. (2011) Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail. Developmental Biology. 354(1):102-110
Ren, X., Gomez, G.A., Zhang, B., and Lin, S. (2010) Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood. 115(26):5338-5346
Gourronc, F., Ahmad, N., Nedza, N., Eggleston, T., and Rebagliati, M. (2007) Nodal activity around Kupffer's vesicle depends on the T-box transcription factors notail and spadetail and on notch signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(8):2131-2146
Muyskens, J.B., and Kimmel, C.B. (2007) Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer. Mechanisms of Development. 124(1):35-42

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