ZFIN Morpholino: MO1-wwtr1

Target Location

Genome Build: GRCz11Chromosome: 22

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-wwtr1

Expressed Gene	Anatomy	Figures
fli1	vascular endothelium	Fig. 7 from Pappalardo et al., 2015
nkx2.4b	thyroid primordium	Fig. 3 from Pappalardo et al., 2015
pax2a	thyroid primordium whole organism	Fig. 3 , Fig. 4 from Pappalardo et al., 2015
pax8	thyroid primordium	Fig. 3 from Pappalardo et al., 2015
rfng	(not) rhombomere 1 posterior margin (not) rhombomere 2 posterior margin (not) rhombomere 3 posterior margin (not) rhombomere 4 posterior margin (not) rhombomere 5 posterior margin (not) rhombomere 6 posterior margin (all 6)	Figure 5 from Cayuso et al., 2019

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Phenotype

Phenotype resulting from MO1-wwtr1

Phenotype	Fish	Figures
aortic arch dysplastic, abnormal	WT + MO1-wwtr1	Fig. 7 from Pappalardo et al., 2015
determination of heart left/right asymmetry disrupted, abnormal	AB/TU + MO1-wwtr1	Figure 1 from Fillatre et al., 2019
heart jogging process quality, abnormal	AB/TU + MO1-wwtr1	Figure 1 from Fillatre et al., 2019
heart tube mislocalised, abnormal	AB/TU + MO1-wwtr1	Figure 1 from Fillatre et al., 2019
pharyngeal vasculature morphology, abnormal	WT + MO1-wwtr1	Fig. 7 from Pappalardo et al., 2015

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Phenotype of all Fish created by or utilizing MO1-wwtr1

Phenotype	Fish	Conditions	Figures
heart tube mislocalised, abnormal	AB/TU + MO1-wwtr1	standard conditions	Figure 1 from Fillatre et al., 2019
determination of heart left/right asymmetry disrupted, abnormal	AB/TU + MO1-wwtr1	standard conditions	Figure 1 from Fillatre et al., 2019
heart jogging process quality, abnormal	AB/TU + MO1-wwtr1	standard conditions	Figure 1 from Fillatre et al., 2019
rhombomere 3 posterior margin rfng expression absent, abnormal	WT + MO1-wwtr1	standard conditions	Figure 5 from Cayuso et al., 2019
thyroid follicle ab-t4 labeling spatial pattern, abnormal	WT + MO1-wwtr1	standard conditions	Fig. 5 from Pappalardo et al., 2015

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Citations

Include unpublished citations

Cayuso, J., Xu, Q., Addison, M., Wilkinson, D.G. (2019) Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. eLIFE. 8:
Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:
Voltes, A., Hevia, C.F., Engel, C., Dingare, C., Calzolari, S., Terriente, J., Norden, C., Lecaudey, V., Pujades, C. (2019) Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation. Development (Cambridge, England). 146(14):
Merrick, D., Mistry, K., Wu, J., Gresko, N., Baggs, J.E., Hogenesch, J.B., Sun, Z., Caplan, M.J. (2018) Polycystin-1 regulates bone development through an interaction with the transcriptional co-activator taz. Human molecular genetics. 28(1):16-30
Nagasawa-Masuda, A., Terai, K. (2017) Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization. PLoS One. 12:e0174633
Agarwala, S., Duquesne, S., Liu, K., Boehm, A., Grimm, L., Link, S., König, S., Eimer, S., Ronneberger, O., Lecaudey, V. (2015) Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. eLIFE. 4:e08201
Pappalardo, A., Porreca, I., Caputi, L., De Felice, E., Schulte-Merker, S., Zannini, M., Sordino, P. (2015) Thyroid development in zebrafish lacking Taz. Mechanisms of Development. 138 Pt 3:268-78
Zhang, J., Yuan, S., Vasilyev, A., Amin Arnaout, M. (2015) The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish. Mechanisms of Development. 138 Pt 3:328-35
Tian, Y., Kolb, R., Hong, J.H., Carroll, J., Li, D., You, J., Bronson, R., Yaffe, M.B., Zhou, J., and Benjamin, T. (2007) TAZ promotes PC2 degradation through a SCF{beta}-Trcp E3 Ligase Complex. Molecular and cellular biology. 27(18):6383-6395
Hong, J.H., Hwang, E.S., McManus, M.T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B.M., Sharp, P.A., Hopkins, N., and Yaffe, M.B. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309(5737):1074-1078

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