Gene
tie1
- ID
- ZDB-GENE-990415-55
- Name
- tyrosine kinase with immunoglobulin-like and EGF-like domains 1
- Symbol
- tie1 Nomenclature History
- Previous Names
-
- tie-1
- sb:eu718
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within blood vessel development; endothelial cell-cell adhesion; and heart development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; pharyngeal arch; and ventral mesoderm. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu718 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns208 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns210 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa9143 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9781 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14772 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20737 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25341 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33892 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40727 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45257 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 11 | 619401 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Length | EGF-like domain | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O73792
|
184 | ||||||||||||||
|
UniProtKB:A0A2R8QM04
|
1027 | ||||||||||||||
|
UniProtKB:G1K2H0
|
1122 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-185C24 | ZFIN Curated Data | |
| Contained in | BAC | CH211-286N19 | Li et al., 2010 | |
| Encodes | EST | eu718 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001346150 (1) | 6189 nt | ||
| Genomic | GenBank:AL807381 (1) | 230718 nt | ||
| Polypeptide | UniProtKB:G1K2H0 (1) | 1122 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- He, Y., Kam, H., Wu, X., Chen, Q., Lee, S.M.Y. (2023) Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption. Chinese Medicine. 18:108108
- Hußmann, M., Schulte, D., Weischer, S., Carlantoni, C., Nakajima, H., Mochizuki, N., Stainier, D.Y.R., Zobel, T., Koch, M., Schulte-Merker, S. (2023) Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. eLIFE. 12:
- America, M., Bostaille, N., Eubelen, M., Martin, M., Stainier, D.Y.R., Vanhollebeke, B. (2022) An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. Cell Reports. 39:110902
- Facchinello, N., Astone, M., Audano, M., Oberkersch, R.E., Spizzotin, M., Calura, E., Marques, M., Crisan, M., Mitro, N., Santoro, M.M. (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nature metabolism. 4:123-140
- Liu, J., Zhang, M., Dong, H., Liu, J., Mao, A., Ning, G., Cao, Y., Zhang, Y., Wang, Q. (2022) Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis. Development (Cambridge, England). 149(23):
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Matrone, G., Jung, S.Y., Choi, J.M., Jain, A., Leung, H.E., Rajapakshe, K., Coarfa, C., Rodor, J., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nature communications. 12:6282
- Matrone, G., Xia, B., Chen, K., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 118(31):
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