ZFIN Morpholino: MO1-chsy1

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-chsy1

Expressed Gene	Anatomy	Figures
msx3	anterior crista primordium posterior crista primordium	Fig. 5 from Li et al., 2010

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Phenotype

Phenotype resulting from MO1-chsy1

Phenotype	Fish	Figures
atrioventricular canal aplastic, abnormal	AB/TU + MO1-chsy1	Fig. 4 , text only from Peal et al., 2009
blood circulation disrupted, abnormal	AB/TU + MO1-chsy1	text only from Peal et al., 2009
ethmoid cartilage malformed, abnormal	WT + MO1-chsy1	Fig. 4 from Li et al., 2010
eye fused with eye, abnormal	WT + MO1-chsy1	Fig. 4 from Li et al., 2010
forebrain medial region aplastic, abnormal	WT + MO1-chsy1	Fig. 4 from Li et al., 2010

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Phenotype of all Fish created by or utilizing MO1-chsy1

Phenotype	Fish	Conditions	Figures
atrioventricular canal aplastic, abnormal	AB/TU + MO1-chsy1	standard conditions	Fig. 4 , text only from Peal et al., 2009
post-vent region morphology, abnormal	AB/TU + MO1-chsy1	standard conditions	text only from Peal et al., 2009
blood circulation disrupted, abnormal	AB/TU + MO1-chsy1	standard conditions	text only from Peal et al., 2009
heart morphogenesis disrupted, abnormal	AB/TU + MO1-chsy1	standard conditions	Fig. 4 , text only from Peal et al., 2009
heart decreased functionality, abnormal	AB/TU + MO1-chsy1	standard conditions	text only from Peal et al., 2009

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Citations

Include unpublished citations

Holmborn, K., Habicher, J., Kasza, Z., Eriksson, A.S., Filipek-Gorniok, B., Gopal, S., Couchman, J.R., Ahlberg, P., Wiweger, M., Spillman, D., Kreuger, J., and Ledin, J. (2012) On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. The Journal of biological chemistry. 287(40):33905-33916
Li, Y., Laue, K., Temtamy, S., Aglan, M., Kotan, L.D., Yigit, G., Canan, H., Pawlik, B., Nürnberg, G., Wakeling, E.L., Quarrell, O.W., Baessmann, I., Lanktree, M.B., Yilmaz, M., Hegele, R.A., Amr, K., May, K.W., Nürnberg, P., Topaloglu, A.K., Hammerschmidt, M., and Wollnik, B. (2010) Temtamy Preaxial Brachydactyly Syndrome Is Caused by Loss-of-Function Mutations in Chondroitin Synthase 1, a Potential Target of BMP Signaling. American journal of human genetics. 87(6):757-767
Tian, J., Ling, L., Shboul, M., Lee, H., O'Connor, B., Merriman, B., Nelson, S.F., Cool, S., Ababneh, O.H., Al-Hadidy, A., Masri, A., Hamamy, H., and Reversade, B. (2010) Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling. American journal of human genetics. 87(6):768-778
Peal, D.S., Burns, C.G., MacRae, C.A., and Milan, D. (2009) Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(12):3103-3110
Zhang, J., Lefebvre, J.L., Zhao, S., and Granato, M. (2004) Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice. Nature Neuroscience. 7(12):1303-1309

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