ZFIN Image: Dasgupta et al., 2024, Figure 6

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Figure Caption

Figure 6—figure supplement 1. sema7a^-/- mutants display impaired synaptic assembly.

(A–F) The plots quantitate the average numbers and areas of presynaptic aggregates from control and sema7a^-/- neuromasts. Significant decreases in the numbers and areas of presynaptic aggregates are observed across development. Three hundred and forty-one, 1229, and 1286 presynaptic aggregates were analyzed from 2 dpf, 3 dpf, and 4 dpf control larvae, respectively. Two hundred and thirty-five, 643, and 419 presynaptic aggregates were analyzed from 2 dpf, 3 dpf, and 4 dpf sema7a^-/- mutant larvae, respectively. (G–L) The plots quantitate the average numbers and areas of postsynaptic aggregates from control and sema7a^-/- neuromasts. Significant decreases in the numbers and areas of postsynaptic aggregates occurred during development. Three hundred and ninety-seven, 1243, and 1300 postsynaptic aggregates were analyzed from 2 dpf, 3 dpf, and 4 dpf control larvae, respectively. Three hundred and four, 651, and 451 postsynaptic aggregates were analyzed from 2 dpf, 3 dpf, and 4 dpf sema7a^-/- mutant larvae, respectively. Means ± SEMs; *** implies p<0.001.

Acknowledgments

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