ZFIN Image: Lai et al., 2024, Fig. 5

Image

Figure Caption

Fig. 5

sdc4 expression affected ECM-associated marker genes during the cardiac repair. Extracellular matrix (ECM)-associated marker genes: tgfb1a, col1a1a, mmp2, and mmp9 were examined by real-time quantitative PCR with or without sdc4 siRNA treatment at 3 and 7 dpci. A After treating sdc4 siRNA, the sdc4 gene expression was down-regulated as expected. Besides, tgfb1a and col1a1a were significantly down-regulated after sdc4 siRNA treatment at 3 dpci. B At 7 dpci, expression of sdc4, tgfb1a, and col1a1a were all significantly reduced in the sdc4 siRNA group. However, mRNA expression of mmp2 was significantly up-regulated after the sdc4 knockdown (*p < 0.05 vs. negative control; ***p < 0.005 vs. negative control; n = 8 per group) (dpci: days post cryoinjury)

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Biol. Rep.