Fig. 5

Fig. 5 (A) Images of the heads of zebrafish embryos in tissue penetration experiments. Different cross-sections of one embryo for 21 and 22 are shown. Incubation time: 24 h. (B) Images of the heads of zebrafish embryos in tissue penetration experiments. Different cross-sections of one embryo for 21 and 22 are shown. Incubation time: 48 h. Final concentration of applied compounds: 50 μM. Green signals indicate either weak autofluorescence (see (a) blank) or the fluorescence generated from compounds. Scale bar represents 40 μm. (C) Transgenic zebrafish with Tg(sox2: sox2-E2A-QF2)^m1517 and Tg(QUAS: nls-mCardinal)^m1637 with red fluorescent nuclei in neural stem and progenitor cells were used and treated with 6, 21 and 22 respectively. Incubation time: 48 h. Final concentration of applied compounds: 50 μM. Temp.: 28.5 °C. Scale bar represents 20 μm.