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Fig. 3 PALM’s effect upon the seizure threshold in the MEST (A), 6 Hz-induced psychomotor seizure threshold (B) and timed iv infusion PTZ (C-E) tests in mice. PALM was given ip 30 min prior to the respective seizure test at doses between 10–80 mg/kg. Each experimental group in the MEST and 6 Hz psychomotor seizure tests consisted of 20 animals, while in the iv PTZ test, experimental groups included 8–14 mice. Results from the MEST and 6 Hz seizure tests are presented in the form of median current strengths (CS50 in mA) with their 95% confidence limits as the error bars, while the iv PTZ test results are shown as mean ± SEM. One-way ANOVA and Dunnett’s multiple comparison test was applied for data analysis; * p < 0.05, * * p < 0.01.