Fig. 4

Fig. 4

Replication analyses. a Forest plot showing the association of rs140926439 with Alzheimer’s disease risk in APOEε4/4 carriers. Significance was considered at P < 0.05. Results across the datasets were combined using fixed-effects inverse-variance weighted meta-analysis. Cochran’s Q test indicated no significant heterogeneity. OR, odds ratio; CI, confidence interval. b Case–control regression sensitivity analyses for rs140926439 in APOEε4/4 carriers. To ensure an independent replication of discovery findings, in ADGC, samples from NIA-AD FBS cohort were excluded and ADSP whole-genome sequencing data was fully excluded. Results across the datasets were combined using fixed-effects inverse-variance weighted meta-analysis. Cochran’s Q test indicated no significant heterogeneity. c Age at onset analyses for rs140926439 in APOEε4/4 carriers. The large confidence intervals in ADSP whole-genome sequencing (WGS) individuals reflect that there were only two case carriers and one of those had an age at onset at 60 years (an outlier compared to other case carriers). Results across the datasets were combined using fixed-effects inverse-variance weighted meta-analysis. Cochran’s Q test indicated no significant heterogeneity