|
Fig. 1 Protein alignment and evolutionary conservation of FBXL proteins in Homo sapiens, D. rerio, and C. elegans. Protein alignment of H. sapiens, D. rerio, and C. elegans (see Supplemental Figure 1 for alignment with other species). The locations of mutations in the zebrafish and C. elegans mutant strains studied are shown: c.813T>A, p.Y271X in zebrafish and g.410_1116del, p.Phe105_Lys308del in C. elegans. Protein alignment of conserved F-box–like domain among H. sapiens, D. rerio, and C. elegans is shown. Percentage homology is shown in gray, and white and black indicate the lowest and highest levels of similarity, respectively.