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Fig. 2
Figure 2. VARS2 is mainly localized in the mitochondria of HEK293A cells. The scale bar is 10 µm long (A). VARS2 expression is significantly reduced according to mRNA and protein levels in HEK293A cells treated with VARS2-specific siRNAs compared to control siRNA (B). HEK293A cells treated with VARS2-specific siRNAs showed significantly increased diacylation/acylation ratio in valyl-tRNA according to northern blot analysis. n = 5, siSCR mean = 0.4, SD = 0.07; siVARS2-1 mean = 0.59, SD = 0.07, p = 0.0013; siVARS2-2 mean = 0.61, SD = 0.08, p = 0.0016 (C). **≤0.01, ***≤0.001.
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