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Fig. 12
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Figure Caption
Figure 12. Representation of two kinetic models for PepT2 transporter
Each configuration represents a state, from I to IV (outside) and from I’ to IV’ (inside). The presteady-state currents arise from the redistribution of the negatively charged transporter between states I’, I and II (blue boxes). The binding of the first external proton to state I accelerates the inward rate constant, while the binding of a second proton to state II leads to state III, effectively slowing down the outward rate. Transitions between I’, I and II are voltage dependent. S represents the binding of the substrate. Modified from Chen et al. (1999) and Sala-Rabanal et al. (2008). [Colour figure can be viewed at wileyonlinelibrary.com]
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Full text @ J. Physiol.