ZFIN Image: Duclaux-Loras et al., 2022, Figure 2

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Figure Caption

Figure 2 Histopathological and ultrastructural MVID features in the intestinal epithelium of patient.

(A) PAS and CD10 staining in control, P1, P2, and P4 duodenal biopsies. Scale bars: 20 μm. (B–D) TEM of P1’s duodenal enterocytes showing ultrastructural features of MVID: regions containing vesicles and tubulovesicular structures (black arrowheads), enlarged lysosomes (green arrowheads), and swollen (i.e., stressed) endoplasmic reticulum (white arrowheads) as well as more or less complex or partially degraded MVIs (yellow arrowheads) and basolateral microvilli (pink arrowheads). Brush border showed defective microvilli anchored deep into the cytoplasm and thickened terminal web (blue arrowheads) or partially depleted microvilli (red arrowheads). Scale bars: 2 μm (B); 1 μm (C); 0.5 μm (D).

Acknowledgments

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